PAF1 transcriptional regulatory sub-network

The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network

NETWORK ID: CN1181

In order to ensure the specificity of data, an ID index is built by the database itself, and each result corresponds to an ID.

CONDITION: mestanolone

IDBRD-K18523449
namemestanolone
typeSmall molecule
molecular formulaC20H32O2
molecular weight304.5
condition dose10 uM
condition time24 h
smilesC[C@]12CCC(=O)C[C@@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@]4(C)O)C

CONDITION TYPE: trt_cp

Compound

CELL LINE: MCF7

Cell lines used for experiments

TRANSCRIPTION FACTOR: PAF1

Transcription regulatory factors corresponding to this network

ARTICLE: mestanolone

[1] Profiling of anabolic androgenic steroids and selective androgen receptor modulators for interference with adrenal steroidogenesis.

[2] Stanazolol derived ELISA as a sensitive forensic tool for the detection of multiple 17α-methylated anabolics.

[3] Efficient oxidizing methods for the synthesis of oxandrolone intermediates.

[4] Detection of urinary metabolites common to structurally related 17alpha-alkyl anabolic steroids in horses and application to doping tests in racehorses: methandienone, methandriol, and oxymetholone.

[5] Analysis of anabolic steroids in the horse: development of a generic ELISA for the screening of 17alpha-alkyl anabolic steroid metabolites.

[6] Preconcentration and spectrophotometric determination of oxymetholone in the presence of its main metabolite (mestanolone) using modified maghemite nanoparticles in urine sample.

[7] Identification and quantification of metabolites common to 17alpha-methyltestosterone and mestanolone in horse urine.

[8] The protein anabolic action of mestanolone.

[9] Studies on anabolic steroids--8. GC/MS characterization of unusual seco acidic metabolites of oxymetholone in human urine.

Differential expressed genes in this transcriptional regulatory sub-network

| logfc | > 0.45 and P < = 1e-5. If you want to view or download the data, you can click [expand]

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Symbolcontrolcontrolcontrolconditioncondition
HMOX15.23325.17345.16313.3764.0403
SUV39H17.89927.8368.69594.87636.4013
WIPF27.19446.84916.77115.24475.7002
EML38.02667.79628.19816.1856.5949
PXN11.748311.964811.730410.284910.6294
ZNF2747.40867.11977.19445.74585.9685
VAPB9.51348.97729.09416.65397.8862
SCARB18.89318.73879.78076.36797.5753
LSM68.0697.73158.26885.95116.7709
SACM1L8.46848.48587.49346.05966.5202
ABCF39.33998.65399.80977.09117.482
RAD9A7.25727.22237.23616.05965.78
TSTA36.71896.71516.85925.24475.4966
ABCB68.81568.45459.24765.95116.7866
CIRBP10.71659.674310.85938.36458.6701
CRTAP6.21766.6567.06754.64295.2698
ANXA79.67239.40229.53167.69787.9076
SKIV2L7.79857.50498.16166.27856.4269
ATP1B18.87848.57559.91915.95117.3499
ADO6.68136.34856.19774.64295.1556
RNH110.806210.655910.64169.53899.5282
NOSIP8.63488.52849.15427.13537.5479
ZMYM210.720610.517810.4688.36459.4507
GRN10.178710.754411.05356.57928.159
TLE19.42029.23389.89017.76778.2026
ACOT98.43427.7648.37435.47115.9857
F1210.275210.645610.29658.03559.1524
CAPNS110.31829.98110.88248.63277.7434
SF3B29.20068.7289.8826.9127.7516
MATR39.78849.86359.92758.36968.8674
CD8112.971912.623312.992110.473810.3851
S100A1011.930412.030111.91656.95189.905
TRIM2811.333510.569611.90668.35159.2542
STOM8.44677.07867.81785.47935.5813
CYC111.732212.098812.15748.910.5746
SYNGR212.421512.60811.708410.483710.423
HDAC110.653711.217810.54169.3359.4343
ERP299.499610.285211.19686.9448.2472
TALDO19.97839.288710.03828.09537.9629
NQO111.494811.058912.20179.52519.504
WSB29.99468.79739.52066.23287.7937
CYB5R310.485210.232410.88317.3989.1013
CD557.85098.15637.40245.93385.9517
CIB19.84549.19889.58865.3957.0332
ARPC1B10.283810.625311.12217.30318.5825
CHMP2A9.39669.12128.85055.01617.1814
RAB1312.096812.637212.236911.11910.4767
CTSH9.21337.96268.68695.584.7767
EPS811.299110.300312.21366.97216.8028
CTPS17.92728.23259.08016.07026.892
SNRPD112.042711.763912.068910.752210.7979
LSM411.102410.500511.16187.18229.2627
UBE2S11.674811.918913.0675.79588.9773
GCC26.98786.33326.33354.39685.2705
ZMPSTE2411.093611.173211.36178.46579.6061
SLPI4.98795.14464.97613.40423.2206
BMS19.41479.14049.18087.25558.1459
TBC1D46.25384.09885.14390.02692.4934
PROCR11.621711.470611.57679.62410.5095
COIL10.27249.972710.19177.98888.843
EMP35.24945.5356.35281.88522.3429
GCLM8.09537.01587.90535.16655.9064
WWP27.93388.00338.45455.3926.8092
PCBP213.813513.61514.258111.293612.5107
TSC22D28.83338.76287.84915.81526.7702
TFF112.336812.800612.99436.05239.0827
ARL4A4.28393.89084.61772.55973.0634
PSCA6.63376.4287.38043.39874.747
CCDC229.20258.97759.25567.34587.9546
GRB147.81677.02147.5174.845.3659
NDRG27.50068.41249.47634.16586.188
KAT57.26937.87787.69325.98816.3769
RPL36AL12.561612.247112.821910.734810.2182
ATP6AP18.49028.45889.3766.29717.0964
CLIC110.618910.516810.4318.58268.5543
TAPBP8.00357.74588.49596.71636.3834
NEU17.75558.12667.86716.66366.6097
SLC25A1112.907911.750811.67979.449610.2479
ISCU10.2589.1899.84857.90227.9906
NR2F29.35199.47710.6717.97686.3034
HIGD2A13.021213.076913.651811.780511.8857
PRPS18.38659.40248.55966.677.2773
POP710.05210.066510.29738.78738.7386
PRKAA18.1988.43477.91876.42126.793
TNFSF137.39216.18326.13794.40414.6848
YWHAE13.600813.694113.370511.255912.1994
SERPINB610.42099.662110.88066.60698.0129
BAG17.85957.20297.73025.83645.5651
TMPRSS25.47065.16785.03071.87113.4992
B3GALNT17.36726.50287.644.78995.5695
EIF4B9.81539.10849.66226.18287.3351
AHNAK8.60578.2167.77785.17696.1296
PTOV19.97529.792210.37138.70868.76
POLDIP37.26057.19867.30165.64766.2445
PSME48.86288.15628.80466.3027.3036
CMTR17.92047.93437.78246.03086.6567
MFSD59.70919.28329.38697.18428.0382
GNPTAB8.58217.44847.61875.75335.9221
APRT12.443512.46213.254910.905410.63
HNRNPA111.860212.561611.93049.974710.8243
BRD26.59586.76237.16645.58114.7515
SEC16A7.05217.35097.38493.88275.7045
TRIOBP8.51268.16018.28285.98567.0478
HLA-E6.35466.51846.3484.77944.8436
COPZ18.73938.92399.38327.49537.6471
NUCKS112.548712.066713.61510.036710.4013
GOLPH39.41899.42949.35037.42537.969
EMC310.1599.73549.8416.79878.4559
AKIRIN17.59547.21147.57065.34286.0261
SPCS19.44028.59479.15587.25497.4979
VPS519.51479.35159.76217.80038.0119
PRC19.84279.81049.37976.64148.2199
TSEN3411.011211.112910.97028.81489.2352
MLPH12.150911.99911.92567.05679.8835
RMND5B9.96619.5159.75747.90288.5851
SPATS28.69998.56858.5347.40077.0393
U2AF210.05239.96619.62227.55118.0574
SFXN19.99119.75110.85688.37228.4131
MRPS309.19488.30299.13644.91516.1381
THEM68.79688.79028.75816.8427.6726
NDUFA311.237410.67410.65858.44258.4321
ZDHHC78.76647.87287.98435.57286.7766
SLC25A158.0937.9418.3135.43976.5454
LXN1514.900413.720212.326812.1541
BRF27.39827.14917.67065.42816.1461
WWOX6.98086.38676.89755.17955.0418
MACROD19.53819.520810.35346.99488.2841
HSPA149.26188.54578.36747.20477.0735
SLC6A148.18356.45068.10424.60935.2406
RBM238.82248.95568.9766.76487.6851
THADA7.26656.96437.15585.73165.939
ZNF58010.981510.98510.97469.41969.8936
KLHDC48.57468.30438.32917.09427.2917
SF3B510.904710.810110.79139.13869.8451
IMP39.35758.98419.72657.34558.1142
UGCG6.0596.44117.06573.82244.5044
KANSL28.48558.64998.44296.48756.9357
CSPG57.11846.68827.24295.2375.3433
SSH39.6979.709910.38128.29718.4904
ZMIZ26.13835.60136.5034.73893.965
CORO1B11.472111.595211.63969.05599.4652
CYP1A26.16826.54677.224.39685.2222

PAF1 transcriptional regulatory sub-network

The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network

ARTICLE: PAF1

[1] PD2/PAF1 at the Crossroads of the Cancer Network.

[2] PAF1 regulation of promoter-proximal pause release via enhancer activation.

[3] Emerging Insights into the Roles of the Paf1 Complex in Gene Regulation.

[4] RNA Polymerase II-Associated Factor 1 Regulates Stem Cell Features of Pancreatic Cancer Cells, Independently of the PAF1 Complex, via Interactions With PHF5A and DDX3.

[5] Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1.

[6] The Paf1 complex transcriptionally regulates the mitochondrial-anchored protein Atg32 leading to activation of mitophagy.

[7] PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II.

[8] Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD.

[9] Competition between PAF1 and MLL1/COMPASS confers the opposing function of LEDGF/p75 in HIV latency and proviral reactivation.

[10] The Paf1 Complex Broadly Impacts the Transcriptome of Saccharomyces cerevisiae.