ZNF711 transcriptional regulatory sub-network
The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network
NETWORK ID: CN1239
In order to ensure the specificity of data, an ID index is built by the database itself, and each result corresponds to an ID.
CONDITION: triptolide
| ID | BRD-K39484304 |
| name | triptolide |
| type | Small molecule |
| molecular formula | C20H24O6 |
| molecular weight | 360.4 |
| condition dose | 10 uM |
| condition time | 24 h |
| smiles | CC(C)[C@]12O[C@H]1[C@@H]1O[C@]11[C@]3(O[C@H]3C[C@H]3C4=C(CC[C@]13C)C(=O)OC4)[C@@H]2O |c:17| |
CONDITION TYPE: trt_cp
Compound
CELL LINE: MCF7
Cell lines used for experiments
TRANSCRIPTION FACTOR: ZNF711
Transcription regulatory factors corresponding to this network
ARTICLE: triptolide
[1] Triptolide and Its Derivatives as Cancer Therapies.
[2] Triptolide-targeted delivery methods.
[3] Toxicity of triptolide and the molecular mechanisms involved.
[4] Triptolide Inhibits Lung Cancer Cell Migration, Invasion, and Metastasis.
[5] Triptolide: Medicinal chemistry, chemical biology and clinical progress.
[9] Preclinical Pharmacokinetics of Triptolide: A Potential Antitumor Drug.
[10] Effects of puerarin on the pharmacokinetics of triptolide in rats.
Curated target protein/gene of this condition/drug
Protein target or gene target of this condition curated by previous studies and their associated KEGG pathways are shown below
| Target Gene | KEGG pathway |
|
RELA 
|
hsa04658 
|
Differential expressed genes in this transcriptional regulatory sub-network
| logfc | > 0.45 and P < = 1e-5. If you want to view or download the data, you can click [expand]
| Symbol | control | control | control | condition | condition |
|---|---|---|---|---|---|
| CCND1 | 8.0633 | 7.8112 | 8.9815 | 4.1184 | 4.9141 |
| NFKBIA | 8.8996 | 8.6821 | 9.4091 | 3.0624 | 4.9535 |
| PLK1 | 10.5746 | 10.2675 | 11.0834 | 4.9822 | 6.8854 |
| CDKN1B | 13.1326 | 12.5929 | 12.8649 | 5.4481 | 7.3532 |
| IGF1R | 9.0573 | 9.2177 | 9.6032 | 5.2271 | 5.1027 |
| EZH2 | 8.5722 | 8.4033 | 7.958 | 3.3888 | 4.6863 |
| RPN1 | 13.6289 | 13.3019 | 13.4856 | 10.8128 | 11.259 |
| GABPB1 | 9.7216 | 9.1181 | 9.5108 | 5.8617 | 6.1253 |
| XBP1 | 13.5128 | 13.4687 | 12.9342 | 8.4452 | 7.1232 |
| SOX4 | 8.8816 | 8.5632 | 9.4426 | 4.1184 | 5.3659 |
| ACBD3 | 7.1025 | 6.0766 | 6.6272 | 3.3888 | 3.4692 |
| USP22 | 10.8981 | 11.9288 | 12.0431 | 6.0475 | 6.9322 |
| CHERP | 7.8611 | 8.4021 | 7.7387 | 4.4497 | 4.6429 |
| MSH6 | 10.3553 | 9.7986 | 10.4833 | 7.6628 | 7.1819 |
| UBE2C | 12.2506 | 12.0381 | 12.2981 | 5.2271 | 5.6744 |
| DNAJB1 | 10.0702 | 9.4695 | 9.9134 | 5.2271 | 5.4453 |
| VAPB | 9.5134 | 8.9772 | 9.0941 | 6.5198 | 6.5375 |
| NUP88 | 10.9556 | 10.8345 | 10.694 | 7.379 | 7.9089 |
| ATMIN | 6.9973 | 8.3202 | 7.9454 | 3.7509 | 4.3744 |
| GLOD4 | 11.0462 | 9.9524 | 10.674 | 7.0186 | 6.4748 |
| TMEM97 | 9.1053 | 9.2105 | 9.8297 | 6.3587 | 6.2075 |
| NUP62 | 8.2342 | 7.8679 | 8.5177 | 4.9822 | 3.7645 |
| B4GAT1 | 8.504 | 7.1941 | 8.33 | 4.1184 | 4.6429 |
| PCMT1 | 11.4168 | 11.5499 | 11.5232 | 8.4452 | 9.3033 |
| MYC | 9.7003 | 9.8824 | 10.661 | 5.6272 | 6.7755 |
| RAE1 | 11.376 | 11.7076 | 11.6163 | 6.1668 | 7.7662 |
| CDK1 | 10.7429 | 10.9551 | 11.2178 | 7.1406 | 7.7178 |
| BCL7B | 6.3071 | 6.2833 | 6.6222 | 4.1184 | 4.2474 |
| FHL2 | 10.9977 | 10.502 | 10.8897 | 6.4401 | 6.6343 |
| PRSS23 | 11.9442 | 11.7657 | 11.5499 | 6.2752 | 7.9475 |
| BLVRA | 9.7981 | 9.448 | 9.7385 | 7.0186 | 7.1467 |
| POLG2 | 8.5821 | 8.606 | 8.5723 | 4.9822 | 5.017 |
| USP7 | 7.1591 | 7.228 | 7.3702 | 4.1184 | 3.7749 |
| CHEK2 | 9.2799 | 8.5823 | 8.8722 | 5.4481 | 6.2021 |
| CGRRF1 | 9.8995 | 9.8066 | 10.3487 | 5.8617 | 6.9564 |
| NUP85 | 11.0897 | 11.0065 | 10.8777 | 8.3169 | 8.4116 |
| GTPBP8 | 9.8521 | 9.3487 | 10.0624 | 6.892 | 6.394 |
| TIMM9 | 14.6282 | 14.5846 | 13.9708 | 7.7424 | 7.3937 |
| CDK19 | 7.9502 | 7.8903 | 7.5462 | 5.4481 | 5.2004 |
| NRIP1 | 11.1621 | 11.1815 | 10.9277 | 3.7509 | 5.5501 |
| RNPS1 | 13.7478 | 14.9442 | 13.5462 | 10.0544 | 9.7131 |
| RPP38 | 9.0276 | 8.1653 | 8.0666 | 5.2271 | 4.9677 |
| BAG3 | 12.9606 | 13.054 | 13.0903 | 4.4497 | 7.2459 |
| CEBPZ | 9.112 | 8.9049 | 8.6541 | 6.5198 | 6.5893 |
| LASP1 | 8.2902 | 7.582 | 8.1271 | 4.9402 | 5.4668 |
| DLGAP5 | 9.5539 | 9.8359 | 9.5666 | 5.9396 | 6.0877 |
| UBE4A | 8.2547 | 7.972 | 7.7948 | 4.571 | 5.0901 |
| IST1 | 10.2447 | 10.3056 | 10.4599 | 8.1434 | 7.8734 |
| TRA2B | 10.6886 | 10.486 | 10.5095 | 8.3454 | 8.6002 |
| AMD1 | 7.9005 | 7.1714 | 7.9213 | 3.254 | 2.4117 |
| PLEKHB2 | 8.4056 | 8.2563 | 7.9789 | 5.8511 | 5.9011 |
| PTDSS1 | 9.7437 | 9.9329 | 9.7441 | 4.8624 | 6.5052 |
| DKC1 | 10.0205 | 10.6036 | 10.7971 | 6.0989 | 6.3639 |
| SNW1 | 9.2885 | 9.0911 | 9.1573 | 6.0406 | 6.4702 |
| DDX39A | 12.797 | 13.3384 | 13.7531 | 8.7794 | 9.0611 |
| ADNP | 8.796 | 8.5334 | 8.3269 | 5.6804 | 5.6129 |
| ABCE1 | 8.2285 | 8.4198 | 8.8357 | 5.5377 | 6.1708 |
| BLVRB | 12.4529 | 12.5855 | 12.9146 | 9.7054 | 9.4646 |
| SREBF1 | 9.7404 | 9.1524 | 9.629 | 6.9751 | 6.5509 |
| SNRPD1 | 12.0427 | 11.7639 | 12.0689 | 9.2616 | 9.634 |
| TOB1 | 10.257 | 10.61 | 10.1748 | 7.104 | 7.4149 |
| USP8 | 8.7202 | 8.0434 | 8.7269 | 5.237 | 5.956 |
| PSMD6 | 13.2345 | 12.6459 | 12.4529 | 8.5831 | 8.8678 |
| UBE2S | 11.6748 | 11.9189 | 13.067 | 6.2383 | 7.0885 |
| BCAS2 | 11.5016 | 12.4806 | 12.2471 | 6.3757 | 8.0261 |
| MGAT2 | 8.4514 | 8.7693 | 8.0915 | 5.4877 | 4.4273 |
| GPRC5A | 9.3713 | 9.6671 | 9.1736 | 4.7965 | 6.0485 |
| HDDC2 | 8.9405 | 8.5366 | 8.6379 | 6.3664 | 5.7598 |
| ARF6 | 10.8871 | 11.6226 | 10.7285 | 8.3532 | 8.1578 |
| RNF6 | 8.6819 | 8.3941 | 8.6631 | 5.7975 | 5.0382 |
| TMPO | 10.2554 | 10.0523 | 9.9865 | 7.1623 | 7.1732 |
| CAMLG | 9.3408 | 9.6321 | 9.6896 | 6.4769 | 7.2805 |
| COIL | 10.2724 | 9.9727 | 10.1917 | 7.2146 | 6.2926 |
| UTP18 | 12.1777 | 11.6015 | 12.2506 | 9.3049 | 9.0203 |
| TDG | 11.4997 | 11.6483 | 11.1411 | 8.2902 | 6.8603 |
| JUND | 12.2596 | 12.1475 | 12.7646 | 7.9352 | 9.3397 |
| VRK1 | 9.5562 | 8.5489 | 9.1614 | 5.8274 | 6.021 |
| TMEM243 | 8.6528 | 7.86 | 9.0067 | 3.8528 | 4.7307 |
| GCH1 | 10.5852 | 9.5364 | 10.2182 | 3.9608 | 4.9694 |
| DBF4 | 8.2191 | 8.4318 | 9.005 | 4.2002 | 4.8292 |
| CHD1 | 7.6703 | 7.4472 | 7.8311 | 5.4269 | 5.5131 |
| TFF1 | 12.3368 | 12.8006 | 12.9943 | 0.0269 | 1.8852 |
| SLC22A5 | 6.7463 | 7.2344 | 8.0056 | 2.815 | 3.0979 |
| SAC3D1 | 8.2726 | 8.2647 | 8.6555 | 5.486 | 5.6819 |
| GEMIN4 | 8.7679 | 9.4142 | 9.1454 | 5.8528 | 5.8601 |
| PPP1R8 | 8.5731 | 8.5742 | 8.7726 | 6.3143 | 6.1924 |
| SF1 | 9.8564 | 9.7023 | 9.9949 | 7.1581 | 7.639 |
| TECR | 10.324 | 10.9047 | 10.9424 | 8.3787 | 7.924 |
| SRSF3 | 10.1304 | 9.8286 | 9.8718 | 7.4783 | 7.1939 |
| XPO1 | 11.0192 | 9.9027 | 10.5882 | 7.3349 | 7.5079 |
| BSCL2 | 9.1918 | 9.1618 | 9.8245 | 6.4274 | 6.586 |
| NEU1 | 7.7555 | 8.1266 | 7.8671 | 5.469 | 5.628 |
| KDM2A | 7.2968 | 7.0269 | 7.2049 | 4.2743 | 4.8394 |
| NHP2 | 14.9004 | 14.6088 | 14.4338 | 11.9105 | 11.8437 |
| POLR2H | 11.0232 | 10.2013 | 10.8697 | 7.4394 | 8.0185 |
| UTP3 | 8.4295 | 8.237 | 9.0239 | 4.7168 | 4.9617 |
| HSF2 | 8.0009 | 7.6903 | 8.0521 | 4.4341 | 5.3725 |
| CDKN3 | 10.7522 | 10.4491 | 10.2127 | 7.0223 | 5.8645 |
| RHOD | 9.5669 | 9.7037 | 9.7309 | 5.3766 | 6.2455 |
| TPX2 | 9.8835 | 9.8977 | 10.6312 | 5.8926 | 6.9824 |
| RPS6KB1 | 11.2836 | 11.478 | 11.5413 | 8.8271 | 8.6365 |
| EIF4B | 9.8153 | 9.1084 | 9.6622 | 5.8644 | 6.7549 |
| SMARCE1 | 10.152 | 10.0056 | 10.0106 | 7.9804 | 7.7867 |
| RBM25 | 9.2989 | 9.2219 | 9.2908 | 6.218 | 6.8007 |
| ELF1 | 7.931 | 7.8921 | 8.4093 | 4.6751 | 5.2377 |
| TRIM33 | 9.3117 | 9.8962 | 9.2651 | 6.8246 | 7.128 |
| YTHDC1 | 9.0009 | 8.1673 | 9.075 | 5.5318 | 5.9446 |
| CEBPB | 15 | 15 | 15 | 12.5889 | 11.8719 |
| ZNHIT3 | 9.3901 | 8.9649 | 9.3557 | 6.0523 | 6.1238 |
| NME4 | 9.8662 | 9.9766 | 10.4805 | 7.4583 | 6.9482 |
| TSPYL4 | 6.7742 | 6.7655 | 6.7335 | 4.1658 | 4.7586 |
| TSPYL5 | 8.338 | 7.3313 | 8.5219 | 1.4402 | 3.2997 |
| PTPN2 | 7.3057 | 7.0657 | 7.5916 | 4.4246 | 4.8099 |
| SEC16A | 7.0521 | 7.3509 | 7.3849 | 4.0241 | 4.612 |
| SF3A1 | 8.2042 | 8.2302 | 8.7574 | 5.3188 | 5.9184 |
| WDR6 | 9.4709 | 8.6222 | 9.2316 | 5.7358 | 5.6631 |
| TRMT112 | 13.2245 | 12.7748 | 13.6101 | 9.794 | 10.3713 |
| SUPT16H | 10.7309 | 10.9011 | 11.0705 | 7.9991 | 7.9679 |
| BAZ1A | 10.3134 | 9.5052 | 10.1806 | 4.8761 | 5.7172 |
| ASNSD1 | 8.5227 | 8.5354 | 8.624 | 6.1347 | 5.8103 |
| NMD3 | 9.6067 | 9.3503 | 9.7404 | 7.043 | 6.5562 |
| GGNBP2 | 7.9794 | 7.3908 | 7.5541 | 5.0841 | 5.2237 |
| AP5M1 | 9.3528 | 9.5747 | 9.4537 | 6.016 | 6.7697 |
| ALG5 | 10.2235 | 10.1323 | 11.1278 | 7.0167 | 6.6545 |
| NUP54 | 10.4627 | 10.6424 | 10.1525 | 6.3085 | 7.5933 |
| SS18L2 | 9.2316 | 8.9815 | 8.8916 | 5.2439 | 6.2452 |
| U2AF2 | 10.0523 | 9.9661 | 9.6222 | 7.0805 | 7.1302 |
| TRIAP1 | 10.9892 | 10.5708 | 11.7558 | 7.4741 | 6.9991 |
| RIOK2 | 8.5665 | 8.4887 | 8.1065 | 5.7731 | 6.222 |
| MRGBP | 9.645 | 9.3605 | 9.5677 | 7.3119 | 7.4663 |
| EIF2AK3 | 9.0994 | 9.6694 | 9.78 | 5.9286 | 6.1989 |
| NXT1 | 9.3086 | 9.4402 | 9.6774 | 6.1096 | 6.12 |
| CCDC59 | 9.7134 | 9.6752 | 9.8678 | 6.4364 | 7.3931 |
| LSM8 | 12.3458 | 12.7206 | 12.1994 | 8.2411 | 9.4892 |
| HSPA14 | 9.2618 | 8.5457 | 8.3674 | 5.62 | 4.511 |
| COQ10B | 7.7129 | 7.7743 | 7.5533 | 5.57 | 5.6969 |
| RBM23 | 8.8224 | 8.9556 | 8.976 | 6.3639 | 5.8698 |
| LUC7L2 | 9.1952 | 9.2697 | 9.2579 | 6.3506 | 6.6792 |
| BRCC3 | 8.6014 | 9.0366 | 8.8735 | 6.699 | 6.4558 |
| USP3 | 11.1278 | 12.2276 | 11.3992 | 8.0555 | 8.2092 |
| TM2D3 | 8.854 | 8.3271 | 8.8133 | 5.7428 | 5.5741 |
| UGCG | 6.059 | 6.4411 | 7.0657 | 0.5711 | 2.5363 |
| KANSL2 | 8.4855 | 8.6499 | 8.4429 | 6.2294 | 5.9546 |
| OXLD1 | 10.9732 | 10.7451 | 10.8871 | 8.4338 | 8.2655 |
| C11orf24 | 7.3526 | 7.411 | 7.7443 | 5.3184 | 4.9992 |
ZNF711 transcriptional regulatory sub-network
The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network
ARTICLE: ZNF711
[1] Clinical Significance of ZNF711 in Human Breast Cancer.
[2] Prediction of competing endogenous RNA coexpression network as prognostic markers in AML.
Transcription factor KEGG
The KEGG pathway of the TF in this TRN is shown below