HCFC1 transcriptional regulatory sub-network

The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network

NETWORK ID: CN1272

In order to ensure the specificity of data, an ID index is built by the database itself, and each result corresponds to an ID.

CONDITION: anagrelide

IDBRD-K62200014
nameanagrelide
typeSmall molecule
molecular formulaC10H7Cl2N3O
molecular weight256.08
condition dose10 uM
condition time24 h
smilesClc1ccc2N=C3NC(=O)CN3Cc2c1Cl |t:5|

CONDITION TYPE: trt_cp

Compound

CELL LINE: MCF7

Cell lines used for experiments

TRANSCRIPTION FACTOR: HCFC1

Transcription regulatory factors corresponding to this network

ARTICLE: anagrelide

[1] Contemporary management of essential thrombocythemia in children.

[2] Contemporary approach to essential thrombocythemia and polycythemia vera.

[3] Anagrelide compared with hydroxyurea in WHO-classified essential thrombocythemia: the ANAHYDRET Study, a randomized controlled trial.

[4] Treatment of essential thrombocythemia in Europe: a prospective long-term observational study of 3649 high-risk patients in the Evaluation of Anagrelide Efficacy and Long-term Safety study.

[5] Long-term efficacy and safety of ruxolitinib versus best available therapy in polycythaemia vera (RESPONSE): 5-year follow up of a phase 3 study.

Curated target protein/gene of this condition/drug

Protein target or gene target of this condition curated by previous studies and their associated KEGG pathways are shown below

Target Gene KEGG pathway

PDE3A

hsa04924

Differential expressed genes in this transcriptional regulatory sub-network

| logfc | > 0.45 and P < = 1e-5. If you want to view or download the data, you can click [expand]

you can download all data

Symbolcontrolcontrolcontrolconditioncondition
FCGR2C5.97856.01515.43024.4454.7798
CLTC11.976612.326811.910511.068211.1912
WIPF27.19446.84916.77115.77675.9474
PXN11.748311.964811.730410.95910.6172
KTN110.061110.3749.33198.30618.1266
TIMELESS10.507110.707610.9149.7039.5637
CAPN17.02486.56037.04415.2755.4165
SMARCA47.20817.05227.45895.2756.2975
ICMT8.32218.33848.73637.35377.364
GALE9.59979.20149.39767.62538.0806
USP77.15917.2287.37025.47046.3243
GPATCH85.60325.49635.48294.30114.5243
KLHL214.1964.05113.9653.24643.0634
TARBP18.2047.86567.68416.45794.541
BAG312.960613.05413.090311.826112.1058
GNA117.23997.46827.54415.86836.4834
RABGGTA8.11628.20488.72287.16537.3855
CAPNS110.31829.98110.88249.09128.4529
GUK110.987210.652610.62199.82979.882
COX4I113.097312.82512.919412.094111.8831
TOMM208.84849.09849.70337.357.972
SRSF1110.034410.08929.69959.04758.6512
NUMA17.95448.25418.32897.0357.1121
S100A1011.930412.030111.916510.066510.9333
RERE6.61646.85136.57315.53085.9297
SYNGR212.421512.60811.708410.921410.4491
PGD7.50126.53667.42315.56185.7592
IFI307.7787.9068.28616.47076.9594
PRKAB18.56198.47748.8517.37867.602
CIB19.84549.19889.58868.28528.1077
DPF27.37387.1987.40266.15186.5028
PARP48.75648.18218.90046.58547.2987
PRPF38.67918.61848.7967.76397.9
CTSH9.21337.96268.68696.01376.0481
PSMD1213.05412.75912.616511.280411.7704
CSNK1G28.5338.94269.07017.75377.275
PIEZO110.536610.95211.11398.7659.3139
PIAS38.32918.44658.27887.47337.3313
CHSY17.53456.77896.66414.93645.8698
GPRC5A9.37139.66719.17367.45977.091
MMD6.66496.29546.58154.25935.4664
SUCO10.28889.91159.83148.38028.1183
COIL10.27249.972710.19179.17448.8659
LLGL28.01727.7358.31766.7324.7567
TDG11.499711.648311.141110.28979.9853
CD1517.58857.34978.34186.11416.5149
KIAA05135.79925.72465.61873.81924.472
KIF238.91069.04089.01958.06888.2331
KRT159.5279.38168.41496.48627.4843
NME312.837212.610212.473111.004210.7193
EMP211.486411.755810.61168.98979.895
PITRM18.48217.42118.89586.40866.4446
TCN16.00418.55039.19853.97253.2909
ALDH3B15.88615.87356.54984.71955.061
HOXC64.53863.8045.7612.2962.5953
TMED37.517.8628.22946.48116.8994
NADK9.06838.7128.87577.98267.813
LGALS311.282212.087112.749310.007710.468
FADS110.468711.206210.66238.89969.6621
KDM2A7.29687.02697.20496.41156.0673
AKR1C27.46736.63776.86074.57214.4344
TM7SF27.45117.27657.24166.13546.5202
CROCCP27.1437.17038.0056.11425.5101
EIF4B9.81539.10849.66228.28257.7316
RBM259.29899.22199.29088.35668.0169
NIPA28.00617.38727.8236.40726.5002
FNBP48.32018.42688.47927.14337.5827
KDM1A9.53019.777510.0448.74358.7756
CDK11A9.36118.83659.29828.01578.0567
NME49.86629.976610.48058.81487.4546
CEMIP5.31565.29345.12223.65714.3782
ANXA214.3237151513.492713.6894
KLC17.88997.59847.43436.60326.402
PCGF28.08997.3338.12746.05966.0839
HNRNPA111.860212.561611.930410.881110.9123
CDC42EP48.90319.43439.30757.71227.1254
AKR1C17.88687.51617.30275.72355.0476
NPLOC48.47218.0618.3336.90747.0866
YTHDF28.2097.99448.31676.06817.1534
SLTM7.74588.30627.72256.92326.7121
VPS519.51479.35159.76218.24097.4195
FN3KRP9.26918.99278.9198.14597.8379
ATG1018.98828.7988.40947.68647.7403
ZC3H7A8.39837.8498.17156.8447.1827
KANK26.36195.90846.30254.29594.8018
SNRNP2512.218512.986112.960611.488311.1634
PNPO9.86549.81989.61458.9238.3284
ECHDC26.65156.36386.49825.24324.2593
YRDC6.28546.68676.87885.5565.4319
PITPNC19.28448.29478.89917.61697.2397
LTBP36.23925.61436.96034.78783.8471
MOCOS7.39947.89417.46965.92516.0097
USP486.79176.55837.45865.74745.1296
GDF1513.808714.343713.808710.787312.0152
LDLRAP17.12057.0916.8815.84555.715
TBC1D167.51847.65967.7286.62816.6216
LRRC599.69449.878810.04358.79747.3735
ARAP17.34487.72027.29426.4796.5654
SPSB38.99829.2939.17838.32917.5651
OXLD110.973210.745110.88719.996710.0541
CORO1B11.472111.595211.639610.277210.3326
MTA26.31426.02556.30495.20145.0833
HBZ5.90566.08765.89064.79114.5097
SAA46.05695.52956.01924.97634.3182

HCFC1 transcriptional regulatory sub-network

The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network

ARTICLE: HCFC1

[1] HCFC1 loss-of-function mutations disrupt neuronal and neural progenitor cells of the developing brain.

[2] Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression.

[3] Dystonia-causing mutations in the transcription factor THAP1 disrupt HCFC1 cofactor recruitment and alter gene expression.

[4] HCFC1 is a common component of active human CpG-island promoters and coincides with ZNF143, THAP11, YY1, and GABP transcription factor occupancy.

[5] Hcfc1b, a zebrafish ortholog of HCFC1, regulates craniofacial development by modulating mmachc expression.

[6] Compensatory embryonic response to allele-specific inactivation of the murine X-linked gene Hcfc1.

[7] Heat-Shock Protein 90 Controls the Expression of Cell-Cycle Genes by Stabilizing Metazoan-Specific Host-Cell Factor HCFC1.

Transcription factor KEGG

The KEGG pathway of the TF in this TRN is shown below