NCAPG2 transcriptional regulatory sub-network

The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network

NETWORK ID: CN1276

In order to ensure the specificity of data, an ID index is built by the database itself, and each result corresponds to an ID.

CONDITION: milrinone

IDBRD-K67080878
namemilrinone
typeSmall molecule
molecular formulaC12H9N3O
molecular weight211.22
condition dose10 uM
condition time24 h
smilesCc1[nH]c(=O)c(cc1-c1ccncc1)C#N

CONDITION TYPE: trt_cp

Compound

CELL LINE: MCF7

Cell lines used for experiments

TRANSCRIPTION FACTOR: NCAPG2

Transcription regulatory factors corresponding to this network

ARTICLE: milrinone

[1] Milrinone Dosing and a Culture of Caution in Clinical Practice.

[2] Pharmacotherapy update on the use of vasopressors and inotropes in the intensive care unit.

[3] Which Protocol for Milrinone to Treat Cerebral Vasospasm Associated With Subarachnoid Hemorrhage?

[4] Milrinone Use in Persistent Pulmonary Hypertension of the Newborn.

[5] [Effect of magnesium sulphate and milrinone on cerebral vasospasm after aneurysmal subarachnoid hemorrhage: a randomized study].

[6] Heart failure etiology and response to milrinone in decompensated heart failure: results from the OPTIME-CHF study.

[7] Treatment of Persistent Pulmonary Hypertension of the Newborn: Use of Pulmonary Vasodilators in Term Neonates.

[8] Short-term intravenous milrinone for acute exacerbation of chronic heart failure: a randomized controlled trial.

Curated target protein/gene of this condition/drug

Protein target or gene target of this condition curated by previous studies and their associated KEGG pathways are shown below

Target Gene KEGG pathway

PDE2A

hsa05032

PDE3A

hsa04022

PDE3B

hsa05032

PDE5A

hsa00230

Differential expressed genes in this transcriptional regulatory sub-network

| logfc | > 0.45 and P < = 1e-5. If you want to view or download the data, you can click [expand]

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Symbolcontrolcontrolcontrolconditioncondition
FCGR2B6.16025.89335.9974.39355.0641
GTF2H2B7.32897.85047.29225.75256.1318
ATP6V0A47.54617.25237.09266.2586.3051
LRRC317.14436.96856.45555.99655.1861
SIKE19.85499.629910.29978.99438.9452
TCL1A6.77546.44417.14645.65485.788
TJAP18.62818.86478.42357.7617.8511
RBM12B7.77427.58298.01187.1186.3048
MAPKAPK211.24859.78411.37839.07838.8585
BLCAP9.30589.1389.18298.49798.4886
POLG28.58218.6068.57234.56775.2871
TPD52L28.8118.7737.66767.01987.1212
TIAM16.0995.96785.88025.33395.2104
CDH37.75877.35257.36446.81816.188
ADCY97.57836.44846.43365.43235.1793
PRKCSH10.818210.832311.5210.22919.7487
LGALS3BP7.93958.44758.42675.60087.1763
ZFP36L211.792912.424312.19411.34210.5285
PTDSS19.74379.93299.74418.95187.6783
IFITM16.65066.70326.91714.68174.4852
NBL17.46447.27557.57966.23816.082
LPCAT112.699712.749313.181211.404911.0651
LY6E10.736110.907511.75689.1810.0541
VEZF19.46939.55939.06777.55468.512
BLVRB12.452912.585512.914611.492511.9002
CYP1B110.2549.80149.51458.63467.8757
CTSK9.80399.66688.80927.20968.0551
PFKFB310.121310.831310.43738.66739.2629
DHRS38.26058.27348.63387.29777.2796
PIEZO110.536610.95211.11399.30019.8921
COIL10.27249.972710.19179.38929.4382
DGAT17.64367.5327.596.20166.9844
JUND12.259612.147512.764610.295110.9078
MMP119.09619.5938.70856.51118.1139
STK38.5918.32027.7186.91437.0245
TRIM169.40569.17498.9918.21268.256
SLC25A2410.573310.613310.30319.42169.7574
KIAA05135.79925.72465.61874.33994.6868
PPM1D9.469510.089210.29348.63498.982
EXO18.65468.47428.43247.83447.6521
TFF39.32768.74717.61996.5866.775
ATP7B7.27737.72787.60336.69316.6483
FOXA110.146410.68379.91098.44279.2621
KIF238.91069.04089.01958.1918.306
TFF112.336812.800612.99439.06387.4286
ISG159.20579.53348.89475.92578.0344
GREB17.06466.61436.91955.01535.8287
CSNK1D10.21129.986510.32529.31979.3297
SF19.85649.70239.99498.52199.1284
IRF78.07037.86397.7466.92755.872
CAPN210.099210.614610.04268.58649.4024
MDK10.183211.066410.67638.51819.2732
TNFRSF10B8.6228.5979.84387.12377.6639
SIN3B7.40037.42957.14065.82736.6428
PHLDA211.072111.833611.37649.70310.3312
AP2S112.977412.500513.197211.65212.0363
RPS6KB111.283611.47811.541310.32410.3567
TMPRSS25.47065.16785.03073.71294.3145
PXDN11.568313.230712.290810.153110.431
IFITM311.493911.48311.765710.66969.5901
FASN11.84511.895812.215510.778211.309
CDC3410.262110.266610.26668.77019.0786
CEMIP5.31565.29345.12223.52893.1958
ACKR310.695210.6969.98987.79198.8958
FANCI9.83199.733610.00318.84269.0566
ADCY16.53696.22726.06053.45455.1895
DPY19L49.40458.95979.11517.93548.0468
MXRA85.93435.88585.34084.3414.6038
KLC17.88997.59847.43436.5356.8876
RSAD24.88624.50064.69573.33373.7952
CA1210.02310.510710.35169.07859.0209
GLA9.804210.09139.95568.43538.9529
ARMCX612.828911.98311.926710.470611.1261
ARHGEF107.45676.5757.70485.7035.5415
C38.69529.5039.58126.89577.788
PPDPF12.142412.197712.117110.933311.3348
PDXK8.19698.11268.21947.2497.4357
TSEN3411.011211.112910.97029.985110.1832
RMND5B9.96619.5159.75748.63028.9391
KANK26.36195.90846.30253.60825.2432
UFSP26.30886.40236.01515.17735.0984
PITPNC19.28448.29478.89917.29557.8559
TIPIN8.77028.37258.75037.72237.9352
PIEZO26.8345.98185.9394.77654.2421
ABHD17A9.75819.53259.09788.09778.3596
TCF259.661110.223510.56758.18539.2104
CRISPLD25.7746.43445.04913.18494.4134
GDF1513.808714.343713.80878.990211.7322
UGCG6.0596.44117.06573.14074.0739
MPHOSPH86.2636.92216.35784.55955.0565
LDLRAP17.12057.0916.8816.01895.469
THOC28.49468.01258.21946.52457.2127
DNPEP10.488810.462710.51259.08919.4306
C11orf247.35267.4117.74436.41825.9748
OGFOD310.600210.760810.25089.67529.4494
AEBP18.92118.19247.8167.27026.038
GAS68.4738.03418.09056.64986.9885
SERPINF17.03457.38117.98753.18075.2767
CLDN58.65677.80358.3125.80467.0455
PDE4A8.1878.09078.30956.96827.5294
GFRA16.98636.82156.85556.22046.016
TRH6.08775.69526.48144.66674.6474

NCAPG2 transcriptional regulatory sub-network

The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network

ARTICLE: NCAPG2

[1] NCAPG2 overexpression promotes hepatocellular carcinoma proliferation and metastasis through activating the STAT3 and NF-kappaB/miR-188-3p pathways.

[2] Mutations in NCAPG2 Cause a Severe Neurodevelopmental Syndrome that Expands the Phenotypic Spectrum of Condensinopathies.

[3] NCAPG2 facilitates glioblastoma cells' malignancy and xenograft tumor growth via HBO1 activation by phosphorylation.

[4] NCAPG2 promotes tumour proliferation by regulating G2/M phase and associates with poor prognosis in lung adenocarcinoma.

[5] The condensin component NCAPG2 regulates microtubule-kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores.

[6] Bioinformatics Analysis of Prognostic miRNA Signature and Potential Critical Genes in Colon Cancer.

[7] PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression.

[8] Novel significant stage-specific differentially expressed genes in hepatocellular carcinoma.

[9] KDM3A and KDM4C Regulate Mesenchymal Stromal Cell Senescence and Bone Aging via Condensin-mediated Heterochromatin Reorganization.

[10] Downregulation of lncRNA FGF12-AS2 suppresses the tumorigenesis of NSCLC via sponging miR-188-3p.

Transcription factor KEGG

The KEGG pathway of the TF in this TRN is shown below