RCOR1 transcriptional regulatory sub-network

The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network

NETWORK ID: CN1318

In order to ensure the specificity of data, an ID index is built by the database itself, and each result corresponds to an ID.

CONDITION: nelfinavir

ID	BRD-K74117820
name	nelfinavir
type	Small molecule
molecular formula	C32H45N3O4S
molecular weight	567.8
condition dose	10 uM
condition time	24 h
smiles	Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C

CONDITION TYPE: trt_cp

Compound

CELL LINE: MCF7

Cell lines used for experiments

TRANSCRIPTION FACTOR: RCOR1

Transcription regulatory factors corresponding to this network

ARTICLE: nelfinavir

[1] HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus.

[2] Nelfinavir mesylate.

[3] Effects of repurposed drug candidates nitroxoline and nelfinavir as single agents or in combination with erlotinib in pancreatic cancer cells.

[4] Potentiation of the leishmanicidal activity of nelfinavir in combination with miltefosine or amphotericin B.

[5] Differences in rates of diarrhea in patients with human immunodeficiency virus receiving lopinavir-ritonavir or nelfinavir.

[6] Nelfinavir with concurrent chemoradiotherapy in NSCLC.

[7] New prospects for nelfinavir in non-HIV-related diseases.

[8] Complex drug interactions of the HIV protease inhibitors 3: effect of simultaneous or staggered dosing of digoxin and ritonavir, nelfinavir, rifampin, or bupropion.

[9] HIV protease inhibitors, indinavir or nelfinavir, augment antimalarial action of artemisinin in vitro.

[10] Nelfinavir and lenalidomide/dexamethasone in patients with lenalidomide-refractory multiple myeloma. A phase I/II Trial (SAKK 39/10).

Curated target protein/gene of this condition/drug

Protein target or gene target of this condition curated by previous studies and their associated KEGG pathways are shown below

Target Gene	KEGG pathway
CYP1A2	hsa05204
CYP2B6	hsa00982
CYP2C19	hsa00591
CYP2C9	hsa00830
CYP2D6
CYP3A4	hsa00830
CYP3A7	hsa00140

Differential expressed genes in this transcriptional regulatory sub-network

| logfc | > 0.45 and P < = 1e-5. If you want to view or download the data, you can click [expand]

RCOR1 transcriptional regulatory sub-network

The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network

Transcription factor KEGG

The KEGG pathway of the TF in this TRN is shown below

hsa05016