ZNF711 transcriptional regulatory sub-network

The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network

NETWORK ID: CN1335

In order to ensure the specificity of data, an ID index is built by the database itself, and each result corresponds to an ID.

CONDITION: benactyzine

IDBRD-K85030058
namebenactyzine
typeSmall molecule
molecular formulaC20H25NO3
molecular weight327.4
condition dose10 uM
condition time24 h
smilesCCN(CC)CCOC(=O)C(O)(c1ccccc1)c1ccccc1

CONDITION TYPE: trt_cp

Compound

CELL LINE: MCF7

Cell lines used for experiments

TRANSCRIPTION FACTOR: ZNF711

Transcription regulatory factors corresponding to this network

ARTICLE: benactyzine

[1] Pretreatment and prophylaxis against nerve agent poisoning: Are undesirable behavioral side effects unavoidable?

[2] Repetitive antidotal treatment is crucial in eliminating eye pathology, respiratory toxicity and death following whole-body VX vapor exposure in freely moving rats.

[3] Efficacy of antidotal treatment against sarin poisoning: the superiority of benactyzine and caramiphen.

[4] Pharmacological modulation of soman-induced seizures.

[5] Inhibition effects of benactyzine and drofenine on human serum butyrylcholinesterase.

[6] The influence of anticholinergic drug selection on the efficacy of antidotal treatment of soman-poisoned rats.

[7] The combined action of meprobamate and benactyzine.

Curated target protein/gene of this condition/drug

Protein target or gene target of this condition curated by previous studies and their associated KEGG pathways are shown below

Target Gene KEGG pathway

CHRM5

hsa05010

Differential expressed genes in this transcriptional regulatory sub-network

| logfc | > 0.45 and P < = 1e-5. If you want to view or download the data, you can click [expand]

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Symbolcontrolcontrolcontrolcondition
CX3CL19.84219.702310.17185.6859
HSPD111.080910.912311.19256.5041
PSMB108.96678.69758.68944.5034
PLK110.574610.267511.08345.06
NENF9.22268.87519.22634.5034
POLR2K11.818711.782811.12445.9053
SENP69.02028.5348.42093.873
BIRC511.600211.980412.21856.9925
PDS5A8.67488.44438.32364.5034
XBP113.512813.468712.93428.3843
PXN11.748311.964811.73046.9925
NUP8810.955610.834510.6946.7523
SLC35B110.44229.861310.28085.5435
TCERG19.06828.87519.23424.5034
KIF2C7.96897.87718.0084.5034
PRSS2311.944211.765711.54996.9925
KDELR26.81676.73816.87133.164
ANXA79.67239.40229.53165.06
KEAP19.48869.36199.5835.9053
BLVRA9.79819.4489.73855.5435
STMN19.23718.95629.28175.06
NET19.81389.73429.96255.06
NCOA313.207913.081213.14859.4128
VDAC112.60812.620412.7917.5602
DNAJA31515156.7523
POLG28.58218.6068.57234.5034
ITGB1BP110.027710.04769.55345.06
RAD51C10.604410.039810.51685.5435
NPDC112.215512.238612.84145.5435
PUF6014.203313.928313.69415.9053
STUB11514.784514.76955.9053
NOSIP8.63488.52849.15423.873
DLD12.705112.801912.7597.2511
FIS110.77710.735310.59395.5435
GNAS13.678813.775213.86986.9925
TXNDC910.919111.165210.96653.873
LSM513.965713.605313.62899.8395
NPEPL111.317811.671811.90215.5435
HOMER28.26548.01357.863.873
RPS6KA19.58089.60169.78535.5435
VPS2810.929110.596910.11675.06
ACAT210.01249.975210.01995.06
CHMP4A10.06569.92410.13986.5041
RFNG11.682611.724411.7867.2511
CORO1A8.92878.89588.96974.5034
UBE3C10.400810.10289.71423.873
NRIP111.162111.181510.92775.9053
BAG312.960613.05413.09035.06
TUBB610.493710.239510.21094.5034
CDC4510.683711.230910.85224.5034
SEC24B10.133110.663110.365.7074
EFNB39.927510.054110.36865.4004
GUK110.987210.652610.62196.7479
CD8112.971912.623312.99217.5752
GOT211.663612.112112.27696.196
PTP4A19.88789.99799.765.4737
BZW111.480110.99110.67935.6823
S100A1011.930412.030111.91658.498
PSMB112.693911.925612.10216.6627
CYC111.732212.098812.15745.0001
PSMA714.870114.203314.9648.9377
PSMA512.358912.215512.62046.6112
ADRM112.24512.708612.49657.6455
PTDSS19.74379.93299.74415.4903
RUVBL210.95910.719311.05556.5992
PYGB12.154111.84512.15997.6946
LAMP18.57088.12028.42213.6116
ACSL311.067510.489310.27944.015
RRM213.341813.380712.32685.2622
EPHX18.47648.40688.38994.5662
FIBP9.60719.39719.62225.3318
SLC4A210.831311.187811.27416.5308
PSMB412.102112.259612.44038.1173
SREBF19.74049.15249.6294.2839
PSMD1213.05412.75912.61658.4745
VAMP810.43810.049310.19444.5938
TOB110.25710.6110.17484.9297
ZMPSTE2411.093611.173211.36177.5457
BCAS211.501612.480612.24715.9455
GPRC5A9.37139.66719.17364.7715
PTTG110.540410.270710.20255.6872
TARBP29.54499.53899.50586.1595
FMR110.08049.86269.75816.1433
JUND12.259612.147512.76465.4199
MYL6B9.77049.33199.48234.7016
GCH110.58529.536410.21823.4247
DCTN311.934511.625411.37176.3177
RGS109.36969.46179.23524.9621
ESPL19.502810.15949.79064.5742
PFN212.147512.172111.88316.6599
PFDN41514.396514.79958.7664
RBM4210.83310.458410.70136.8376
PCBP110.139810.053210.39526.1002
CCT5151514.870111.2321
ATP6V1G110.302110.25210.03066.4844
COMT10.109510.10159.93565.0026
PSMB613.442313.055712.97748.9119
PPP4C12.82513.179613.34946.8373
FADS110.468711.206210.66235.3232
GABARAPL29.912510.05479.90315.9436
GLRX310.304210.063310.30795.851
NHP214.900414.608814.43388.8798
SQLE9.17569.46769.29194.4252
MCCC210.506510.308710.59536.8039
RHOD9.56699.70379.73094.7542
PDCD1011.390411.002210.81195.7081
YWHAE13.600813.694113.37058.7859
RHOB9.77419.25289.66682.7124
FASN11.84511.895812.21555.8504
PSMD1411.380510.854811.6925.7843
SPTSSA10.346410.638410.26116.2656
CEBPB15151510.7423
TMEM1319.23128.97578.71884.3591
MGRN19.559310.025510.10695.3288
MZT2A12.885812.672312.91067.903
DPY19L49.40458.95979.11514.895
SCFD19.77229.90519.9515.8773
GPAA19.97919.51559.74795.3978
PPA112.867612.635813.56086.667
CMTM69.17088.49338.56953.097
PPDPF12.142412.197712.11717.5726
NMD39.60679.35039.74045.6752
PRPF40A10.03039.86959.71815.8
NUP5410.462710.642410.15255.7425
TRAPPC2L10.599410.667410.70356.352
CMC211.591711.202411.15376.5238
RPL26L110.301810.474610.54676.1174
PLEKHA18.51918.42288.24424.6861
GPATCH28.77648.61178.48054.666
LSM812.345812.720612.19948.0419
NELFCD11.000111.387411.04495.7183
ZNF58010.981510.98510.97466.151
SLC38A213.4312.716412.82766.4116
GINS210.613511.000110.7326.6708
GDF1513.808714.343713.80877.2751
RACGAP19.868310.453910.08835.5941
CORO1B11.472111.595211.63968.0521
MSLN8.00538.82069.05731.4192

ZNF711 transcriptional regulatory sub-network

The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network

ARTICLE: ZNF711

[1] Clinical Significance of ZNF711 in Human Breast Cancer.

[2] Prediction of competing endogenous RNA coexpression network as prognostic markers in AML.

[3] A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation.

[4] Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders.

[5] Mutations in two large pedigrees highlight the role of ZNF711 in X-linked intellectual disability.

[6] A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation.

[7] Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters.

[8] Fine mapping of Xq11.1-q21.33 and mutation screening of RPS6KA6, ZNF711, ACSL4, DLG3, and IL1RAPL2 for autism spectrum disorders (ASD).

[9] Interactions of cullin3/KCTD5 complexes with both cytoplasmic and nuclear proteins: Evidence for a role in protein stabilization.

[10] ZFX acts as a transcriptional activator in multiple types of human tumors by binding downstream of transcription start sites at the majority of CpG island promoters.

Transcription factor KEGG

The KEGG pathway of the TF in this TRN is shown below