ZNF701 transcriptional regulatory sub-network

The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network

NETWORK ID: CN1396

In order to ensure the specificity of data, an ID index is built by the database itself, and each result corresponds to an ID.

CONDITION: levosulpiride

IDBRD-K51671335
namelevosulpiride
typeSmall molecule
molecular formulaC15H23N3O4S
molecular weight341.4
condition dose10 uM
condition time6 h
smilesCCN1CCC[C@H]1CNC(=O)c1cc(ccc1OC)S(N)(=O)=O

CONDITION TYPE: trt_cp

Compound

CELL LINE: MCF7

Cell lines used for experiments

TRANSCRIPTION FACTOR: ZNF701

Transcription regulatory factors corresponding to this network

ARTICLE: levosulpiride

[1] Systematic review and network meta-analysis: efficacy of drugs for functional dyspepsia.

[2] [Rumination].

[3] Development of levosulpiride-loaded solid lipid nanoparticles and their in vitro and in vivo comparison with commercial product.

[4] Metoclopramide and Levosulpiride Use and Subsequent Levodopa Prescription in the Korean Elderly: The Prescribing Cascade.

[5] Levosulpiride-induced Hyperprolactinemia.

[6] Levosulpiride Increases the Levels of Prolactin and Antiangiogenic Vasoinhibin in the Vitreous of Patients with Proliferative Diabetic Retinopathy.

[7] Pharmacotoxicological aspects of levosulpiride.

[8] Levosulpiride-induced movement disorders.

Curated target protein/gene of this condition/drug

Protein target or gene target of this condition curated by previous studies and their associated KEGG pathways are shown below

Target Gene KEGG pathway

CA12

hsa00910

CA1

hsa00910

CA7

hsa00910

DRD2

DRD3

hsa04728

Differential expressed genes in this transcriptional regulatory sub-network

| logfc | > 0.45 and P < = 1e-5. If you want to view or download the data, you can click [expand]

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Symbolcontrolcontrolcontrolconditioncondition
CAPN95.63536.57216.0784.04554.0564
NDRG47.4017.69787.80885.06935.7455
ENTPD15.34226.23116.32492.31723.6857
LDB37.02697.23437.1985.37875.6005
TBC1D308.20838.59058.23975.81616.3904
MYCL4.71254.97845.07393.29313.3927
HHEX6.96326.58346.07513.87764.2903
OTUB27.60956.75196.7684.81184.7502
CALHM28.41627.48068.16075.48635.9231
CDC4211.085811.701512.41458.5989.0175
PPP1R13B8.30317.40187.11814.96125.0519
CHEK18.28468.1668.06716.45436.5679
MKNK18.95458.41919.60055.13964.3994
NUP8810.242110.702611.04438.22577.7947
KTN19.42158.63658.9045.84885.55
SCYL35.34685.45655.47633.24553.4392
DHRS79.06729.58339.3047.01296.7942
SLC35F28.05347.156.54983.63014.1867
SMAD38.03347.68537.665.57295.7759
OXA1L13.262912.397412.44944.52338.6608
CDCA410.31529.56818.96274.18745.0893
PLSCR39.56138.76268.38765.9646.0085
PXMP211.360811.048410.84318.11478.4542
CLPX9.18348.48188.40276.1825.5751
TXNL4B9.11498.49678.57345.24255.262
TM9SF37.85589.45298.77294.69816.2042
PACSIN39.24358.3918.28466.1826.3496
MACF18.77678.41017.76485.47484.8884
COG29.14839.19149.66914.75454.4703
WASF37.22266.28716.20533.79054.3994
RNPS114.017914.789814.210610.460410.1528
DENND2D9.14838.21228.385.24255.121
ABHD47.55796.35786.75223.79054.1589
RPP389.33539.66678.42426.02285.8542
CIAPIN110.6149.82868.76246.1826.2905
COG79.34649.05429.45565.85755.3929
HACD17.65327.69047.61746.03656.0781
MARCKSL111.145512.081411.94398.54579.548
WSB211.058111.299611.36049.64238.2968
ARIH17.54597.64527.56595.83736.2283
CDK2AP113.471313.450612.59279.91658.5077
RNF417.93838.40938.01876.50666.6097
KIF5B9.752410.034510.21047.52066.4268
CTSH7.07768.70878.80044.26873.2908
CTSK7.13277.15157.33725.10413.6548
EIF2B29.339.89379.65078.00867.7767
ARL29.17869.23859.35257.48426.8837
SRSF510.0969.68619.32077.93577.7975
STAM7.93777.71718.28383.11323.5124
TOE17.9317.57487.48236.15096.0087
F35.3967.06265.82452.66932.6104
ATG148.51218.30559.05726.09246.5817
IDI110.590111.113410.43298.09428.3208
ISG158.64819.109610.01734.63126.6077
TCN19.43967.8937.6681.70044.7322
ARHGAP126.04286.98437.01224.05034.1255
SLC19A29.47619.41428.96726.32157.1396
UCK210.778610.691211.06229.06759.1197
APEX113.326712.77813.480810.411110.2247
SH3GLB16.35486.6586.58745.15514.7898
USP158.01438.32728.97695.55915.8874
RSL1D110.800311.570311.83758.24348.1283
MOAP110.056610.701810.29415.04857.0361
SAMD4A12.213612.997412.51358.27869.8014
KLC18.4447.47847.58614.52584.7558
MAP3K97.23277.41277.21935.70465.8906
POLR2C9.82689.12299.30697.81027.101
MIR22HG4.55135.09814.43071.85672.8143
DLST11.964510.710311.18148.51658.3756
METTL99.842310.056610.40256.88336.9626
TPCN17.54587.17196.67525.31364.8729
EFHD29.747911.263610.54317.83087.8583
POLR3E10.086710.70939.94727.54737.7954
AP5M18.94718.74168.85315.44236.9258
DHX329.09588.93029.33796.00256.8504
PNMA110.485310.26549.90087.96246.4516
GTPBP412.964911.080711.60778.11948.7696
ECHDC25.70865.40845.61783.63564.0513
CHFR10.471310.152310.55978.02366.3238
C14orf1329.00059.17759.02036.80475.7401
MTPAP10.01459.27789.17496.27297.0469
MYO5C7.36678.55617.81053.0523.7566
NIP79.25769.957810.0486.06327.0421
RHOF9.37728.47098.08165.63116.2859
HEATR36.86047.63587.41475.50015.4577
COA78.60788.30488.24515.91616.7558
NXN12.54829.053410.66266.32885.7958
ZFYVE218.17918.09217.8966.52936.0176
TRIM87.20667.63287.74583.69465.3437
USP39.634511.176311.5416.53367.6404
RAB359.23819.10989.4237.08987.5212
FAM174B7.36687.77527.73875.87435.1439
HIP1R10.556710.80410.3738.59648.2685
OTUB111.681211.69211.681410.12229.817
CTNNBIP18.41688.0728.08316.74015.7626
UMOD4.81654.25944.54793.06312.4642

ZNF701 transcriptional regulatory sub-network

The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network

ARTICLE: ZNF701

[1] Monitoring methylation-driven genes as prognostic biomarkers in patients with lung squamous cell cancer.

[2] Mediating effect of genome-wide DNA methylation on suicidal ideation induced by perceived stress.

Transcription factor KEGG

The KEGG pathway of the TF in this TRN is shown below

hsa05168