PTPN11 transcriptional regulatory sub-network

The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network

NETWORK ID: CN2027

In order to ensure the specificity of data, an ID index is built by the database itself, and each result corresponds to an ID.

CONDITION: dovitinib

IDBRD-K85402309
namedovitinib
typeSmall molecule
molecular formulaC21H21FN6O
molecular weight392.4
condition dose10 uM
condition time24 h
smilesCN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O

CONDITION TYPE: trt_cp

Compound

CELL LINE: A549

Cell lines used for experiments

TRANSCRIPTION FACTOR: PTPN11

Transcription regulatory factors corresponding to this network

ARTICLE: dovitinib

[1] FGFR inhibitors: Effects on cancer cells, tumor microenvironment and whole-body homeostasis (Review).

[2] FGF receptors: cancer biology and therapeutics.

[3] Targeting FGFR pathway in breast cancer.

[4] The role of fibroblast growth factor receptor (FGFR) protein-tyrosine kinase inhibitors in the treatment of cancers including those of the urinary bladder.

[5] Dovitinib in patients with gastrointestinal stromal tumour refractory and/or intolerant to imatinib.

[6] Phase 2 study of dovitinib in patients with relapsed or refractory multiple myeloma with or without t(4;14) translocation.

[7] Efficacy of FGFR Inhibitors and Combination Therapies for Acquired Resistance in FGFR2-Fusion Cholangiocarcinoma.

[8] A Systematic Review and Meta-analysis Comparing the Effectiveness and Adverse Effects of Different Systemic Treatments for Non-clear Cell Renal Cell Carcinoma.

Curated target protein/gene of this condition/drug

Protein target or gene target of this condition curated by previous studies and their associated KEGG pathways are shown below

Target Gene KEGG pathway

CSF1R

hsa05202

EGFR

hsa04520

FGFR1

hsa04015

FGFR2

hsa04144

FGFR3

hsa05230

FLT1

hsa04010

FLT3

hsa05230

FLT4

hsa04151

INSR

hsa04010

KDR

KIT

hsa04640

PDGFRA

hsa04144

PDGFRB

Differential expressed genes in this transcriptional regulatory sub-network

| logfc | > 0.45 and P < = 1e-5. If you want to view or download the data, you can click [expand]

you can download all data

Symbolcontrolcontrolcontrolconditionconditioncondition
C1orf549.25318.72298.67016.82514.95925.2279
ACTB13.661313.586613.433810.393211.984410.4804
HSPD110.807611.796412.28485.43599.06957.5819
MNAT111.080310.695911.52058.86349.50379.1084
PAK49.30629.86569.42166.63625.60084.2653
PAICS5.64956.37276.85854.39743.5373.2584
SLC35B111.166712.841411.931710.06167.78467.5206
CDK112.311312.156211.692410.15579.2719.6751
ZMYM29.10499.97649.44846.29594.88854.6096
PSIP18.05578.33649.03983.68514.42814.2003
HSD17B1111.173211.042211.44888.36964.67976.6561
PECR7.57747.94578.10476.19884.20924.3916
TBC1D3110.21310.664610.92588.60846.75647.4995
ARID4B7.21438.21657.36123.76524.88855.8488
RAB3110.20149.28499.59187.18385.15927.4047
DLGAP59.09528.827610.27926.44955.53827.3817
SNRPF13.797314.16113.595210.31199.35269.5325
CBX311.627510.105811.37036.98288.76247.4037
C1D10.70019.701510.81568.31727.0998.3611
TMED211.193411.616612.01599.43629.50238.1316
HNRNPK11.467311.518511.04879.30129.55218.5384
PHB13.604314.410714.013611.80859.59329.4721
BZW110.387410.815310.85387.79256.41026.4306
FUS11.12911.972610.55417.79987.07657.0076
SNX1711.139911.440410.36098.37198.47148.5032
PSMA715151511.311512.617410.8261
GSS11.70512.850312.21538.07988.20039.461
NQO114.078813.1856159.997211.758411.1262
RCN27.99037.71018.73414.72286.33424.2876
PSMA313.369312.986414.036711.441910.277510.5506
MARCKS11.638711.346313.08857.14176.05458.1184
ABCE19.22578.630710.05677.51275.97145.4121
PON211.459510.358410.81534.56942.5786.1672
N4BP2L27.62876.73617.62985.44595.28215.0027
SREBF110.190210.415411.03055.79587.34468.082
MTHFD112.33312.53412.10499.88556.45927.7484
HSPBP111.953313.015611.53479.40678.605810.2171
DNAJC713.206214.22411510.6188.469110.694
SSBP111.936112.383612.7619.29738.962410.5534
TOB18.5228.83198.5324.80736.39875.1445
UBE2S13.95281513.48257.27926.9910.2037
AAGAB10.362610.949310.64067.02956.92287.4389
NBN9.73979.37039.67456.43948.09796.8568
RNASEH2A11.115911.743210.33929.1978.20418.3947
UROS9.29879.67059.43267.23787.90927.4627
ARHGEF110.204510.35749.32276.89597.5637.4902
SPAG59.84499.02249.46537.03477.81546.2429
NDUFB310.642310.965110.07778.17988.47886.9815
PSMA412.363811.727411.789210.03217.99499.5921
PTTG110.753112.418811.58098.87786.1478.294
DYNC1LI212.525311.625211.69739.16945.73098.4982
EMP39.151410.692411.46886.67767.60475.8721
TDG9.19879.299310.29726.32896.62917.6312
CEACAM64.36264.24285.06930.98661.28360.3535
CSTF38.62598.688.88935.99034.91694.4254
PPIH9.41799.514910.09547.38157.13617.7131
SLC12A210.436811.12739.06017.47537.80477.1892
TOM1L19.915710.38649.53896.67184.32813.4745
PDE4D8.66188.04919.14254.67344.2676.5567
NAP1L111.996611.215812.68239.1187.23117.8679
MLF17.78699.16429.39014.67926.6385.1328
POP511.262810.880911.52318.82468.47749.4581
BCL39.640110.64769.5516.50087.19676.2362
PRIM19.07469.28778.80626.5477.15667.0554
HNRNPA2B112.979912.703913.346110.994711.272410.5191
IGFBP17.81687.63747.3435.03354.86094.3626
SNAPC18.84748.2928.47485.79415.65193.2492
RBM4212.098613.183511.19149.87979.05168.7675
AKAP78.09157.40918.51093.17175.72112.1975
SIX19.65278.65898.46756.07536.78775.6068
PRMT113.070214.297713.819410.72676.96817.9953
NDUFB111.464711.354910.98237.22988.91767.8652
PRSS36.77786.61565.61224.03814.38124.2246
ANXA138.45629.02769.59617.31996.65286.6711
RPS14P312.75413.30612.815310.66879.77248.1203
PRDX110.107511.074210.58588.59625.67017.2069
HNRNPUL110.949311.362910.60948.93527.78377.9296
ID19.64339.806911.05574.0787.51126.282
SLC25A1112.26212.678911.39049.20698.69210.2874
TNFRSF10B8.32027.79118.684.79713.48824.8622
ANXA39.23528.13619.06845.05055.13855.7836
COA18.88529.62139.97836.45137.17.6233
NSL19.22228.59478.85156.53893.92516.3366
CRY18.05337.83898.85565.49795.30675.488
CDKN311.900411.43411.87347.45457.93778.6793
APEX113.73481514.046212.39311.232312.0069
B9D111.8312.076311.95879.80279.72659.8755
SPINT210.211411.276811.02658.37588.15518.6273
SERPINB611.441911.733211.70387.38137.22918.7964
EIF4A113.94941514.390611.84411.8639.999
SMARCE111.667211.012811.56529.47717.5527.7553
U2SURP10.853810.526811.05017.72298.28649.3393
CBX511.408511.378911.51859.50599.8589.1339
NUP20510.295510.610110.77897.90028.49828.3078
CHMP78.24529.16278.71375.75356.97816.5576
LIMCH114.24314.164159.15169.679411.3703
NBEAL210.33969.70619.1076.89836.45897.9466
BBS48.34038.48938.58536.57386.52936.5452
GSAP5.45635.44856.17533.23622.15211.0287
ZNF237.18747.34757.88265.53095.38534.8161
HNRNPA112.963412.654611.994610.170710.82989.823
SPG711.64311.373811.31059.94349.34058.8718
CXCL58.4087.85118.95133.42390.78790
SDHC12.832313.340212.290810.76989.647610.9517
EXOSC811.512111.513411.90158.94126.35057.988
GGCT11.038710.408710.17886.57787.37888.8144
ATP2B19.09937.9189.5185.24316.30165.0193
COPZ110.854212.062810.92518.93618.10218.5834
UBE2Z9.08299.34929.59737.44966.33376.1463
RDH119.32428.47359.35156.29796.25787.1118
PRMT510.684811.81211.67919.68398.9639.0609
NUCKS113.17112.89313.31889.005810.71048.3423
POLDIP210.59510.479810.65378.9598.2798.0821
SLTM7.95628.16597.8766.265.93085.9772
CDC279.939710.17259.60988.0387.74746.4488
ASNSD17.99488.49679.13456.40665.39664.9523
FKBP313.000610.775912.92848.47278.16848.1648
COA314.470213.63041511.186811.373811.3491
AMZ211.972611.185410.17258.40887.05758.66
DHX4011.432511.789211.85728.41367.52529.6098
ZWILCH9.99799.541110.50098.39296.15826.5257
SNF811.534711.800111.77299.41367.98039.1365
SFXN110.4229.929510.97118.49578.41738.5185
ACTR68.52247.999.56666.51125.75185.8009
CMC211.4110.850312.3729.147.80857.6653
GLYR19.419.92489.03627.09317.23676.8312
WDR129.30559.46059.67156.66067.17126.5012
SLC25A158.08717.49297.86956.30735.3475.1401
MRPS3311.162811.069511.29317.88087.44297.409
MUC137.68926.95787.60075.27932.43914.5514
SCML17.32676.69975.39612.14643.18493.7147
RPL26L111.527711.186512.62547.74159.56388.9444
ACSF27.61647.93677.98075.87555.96796.3308
MED238.68899.25148.80856.26826.53716.9371
NETO211.846511.610513.32659.12746.89279.4479
PLAC86.35175.07986.54932.04923.51130
PLEKHA19.14599.2479.58026.65787.78816.7325
SYNJ2BP10.550610.669810.81338.47086.14217.6342
ZBTB387.67577.91078.46043.71274.79293.3393
TMEM1005.21626.10174.61612.63252.07953.4804
TIPIN8.79549.38929.17786.5826.47756.1843
OLA111.303211.306411.05468.68747.30749.517
FA2H7.53377.11957.30815.23872.83052.6484
ZNF1210.63049.217310.39488.13136.73677.6528
PCDH99.82459.29038.16496.44963.46121.7222
DEPDC18.39668.34618.3947.03715.78155.5355
PPA29.544511.073310.63396.82126.19136.6645
EMC612.828212.613613.116510.414210.38939.8141
SF3B511.889812.334712.394910.089.28419.656
MIS1210.25569.646710.09937.67747.05576.7025
SPDL18.37249.54119.65336.60767.27516.3456
SPATS2L7.37519.91498.03645.20955.28143.9771
DZIP38.53068.72488.16166.47186.51676.623

PTPN11 transcriptional regulatory sub-network

The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network

ARTICLE: PTPN11

[1] [PTPN11 and the deafness].

[2] Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment.

[3] The Clinical impact of PTPN11 mutations in adults with acute myeloid leukemia.

[4] PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity.

[5] Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia.

[6] Noonan syndrome, PTPN11 mutations, and brain tumors. A clinical report and review of the literature.

[7] Molecular and clinical studies in 107 Noonan syndrome affected individuals with PTPN11 mutations.

[8] Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling.

[9] PTPN11 hypomethylation is associated with gastric cancer progression.

[10] A PTPN11 mutation in a woman with Noonan syndrome and protein-losing enteropathy.

Transcription factor KEGG

The KEGG pathway of the TF in this TRN is shown below