FOS transcriptional regulatory sub-network

The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network

NETWORK ID: CN2475

In order to ensure the specificity of data, an ID index is built by the database itself, and each result corresponds to an ID.

CONDITION: SB-218078

ID	BRD-A06352508
name	SB-218078
type	Small molecule
molecular formula	C24H15N3O3
molecular weight	393.4
condition dose	10 uM
condition time	24 h
smiles	"O=C1NC(=O)c2c1c1c3ccccc3n3[C@H]4CC[C@@H](O4)n4c5ccccc5c2c4c13 |&1:15,&2:18,r|"

CONDITION TYPE: trt_cp

Compound

CELL LINE: MCF7

Cell lines used for experiments

TRANSCRIPTION FACTOR: FOS

Transcription regulatory factors corresponding to this network

ARTICLE: SB-218078

[1] Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer.

[2] Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53.

[3] Checkpoint kinase 1-mediated phosphorylation of Cdc25C and bad proteins are involved in antitumor effects of loratadine-induced G2/M phase cell-cycle arrest and apoptosis.

[4] Structural basis for Chk1 inhibition by UCN-01.

[5] Staurosporine scaffold-based rational discovery of the wild-type sparing reversible inhibitors of EGFR T790M gatekeeper mutant in lung cancer with analog-sensitive kinase technology.

[6] Schedule-dependent synergy between the heat shock protein 90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin and doxorubicin restores apoptosis to p53-mutant lymphoma cell lines.

[7] Chk1 inhibitor synergizes quinacrine mediated apoptosis in breast cancer cells by compromising the base excision repair cascade.

[8] 5‑FU resistance abrogates the amplified cytotoxic effects induced by inhibiting checkpoint kinase 1 in p53‑mutated colon cancer cells.

Curated target protein/gene of this condition/drug

Protein target or gene target of this condition curated by previous studies and their associated KEGG pathways are shown below

Target Gene	KEGG pathway
CHEK1	hsa04110

Differential expressed genes in this transcriptional regulatory sub-network

| logfc | > 0.45 and P < = 1e-5. If you want to view or download the data, you can click [expand]

FOS transcriptional regulatory sub-network

The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network

Transcription factor KEGG

The KEGG pathway of the TF in this TRN is shown below

hsa05171