SMARCA4 transcriptional regulatory sub-network

The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network

NETWORK ID: CN3049

In order to ensure the specificity of data, an ID index is built by the database itself, and each result corresponds to an ID.

CONDITION: spiperone

IDBRD-K55468218
namespiperone
typeSmall molecule
molecular formulaC23H26FN3O2
molecular weight395.5
condition dose10 uM
condition time24 h
smilesFc1ccc(cc1)C(=O)CCCN1CCC2(CC1)N(CNC2=O)c1ccccc1

CONDITION TYPE: trt_cp

Compound

CELL LINE: HEPG2

Cell lines used for experiments

TRANSCRIPTION FACTOR: SMARCA4

Transcription regulatory factors corresponding to this network

ARTICLE: spiperone

[1] Levodopa inhibits the development of lens-induced myopia in chicks.

[2] Inhibition of cutaneous contact hypersensitivity in the mouse with systemic or topical spiperone: topical application of spiperone produces local immunosuppression without inducing systemic neuroleptic effects.

[3] Spiperone: Tritium labelling at high specific activity.

[4] Structure of the dopamine D(2) receptor in complex with the antipsychotic drug spiperone.

[5] Distinct Dopamine D₂ Receptor Antagonists Differentially Impact D₂ Receptor Oligomerization.

[6] Modulation of bleomycin-induced lung fibrosis by pegylated hyaluronidase and dopamine receptor antagonist in mice.

[7] Ketanserin and spiperone as templates for novel serotonin 5-HT(2A) antagonists.

[8] Dopamine displaces [3H]domperidone from high-affinity sites of the dopamine D2 receptor, but not [3H]raclopride or [3H]spiperone in isotonic medium: Implications for human positron emission tomography.

[9] 125I-Spiperone: a novel ligand for D2 dopamine receptors.

Curated target protein/gene of this condition/drug

Protein target or gene target of this condition curated by previous studies and their associated KEGG pathways are shown below

Target Gene KEGG pathway

ADRA1A

hsa04152

ADRA1B

hsa04970

ADRA1D

hsa04970

DRD1

hsa04080

DRD2

hsa05012

DRD3

DRD4

DRD5

hsa04728

HTR1A

hsa04080

HTR1D

hsa04742

HTR2A

hsa04540

HTR2B

hsa04750

HTR2C

hsa04726

HTR6

HTR7

hsa04080

Differential expressed genes in this transcriptional regulatory sub-network

| logfc | > 0.45 and P < = 1e-5. If you want to view or download the data, you can click [expand]

you can download all data

Symbolcontrolcontrolcontrolconditionconditioncondition
FAM169A8.43799.11718.44636.946.75357.0206
VASH26.03075.59895.59994.1794.10544.4684
PROS19.32879.34919.49525.18284.76035.1003
CDK412.808212.960413.3539.175310.391410.7191
AURKB11.078310.539311.30858.45098.18538.4444
AURKA7.96297.94328.06415.79575.26556.2464
HMGA211.361211.451711.50898.43248.68928.6731
ERBB310.11759.33299.68087.14186.34355.9736
TFDP19.567910.328310.44598.2167.84948.1396
PCNA14.581914.562414.694313.004413.163913.2319
PFKL9.19588.52419.14787.31966.53496.5765
PLK113.360913.228413.203611.714111.068311.4187
MYLK6.0016.06445.81424.85164.30284.2349
FGFR412.116611.487711.68536.63466.62598.9452
GSTM25.58495.31095.57754.12484.10394.2249
ICAM37.68347.47137.44425.04584.27684.5866
MCM312.62912.26412.516410.895810.901410.6858
BIRC514.099113.790613.828112.339511.909411.9143
CCNA211.850211.63512.07679.41579.55958.8169
RPA112.047411.901412.024710.603510.721310.7478
LIG110.645910.390310.31696.89446.59746.436
BLCAP12.203612.076712.128610.42989.95849.8391
KIF2C11.553511.064611.21169.8789.57029.5353
B4GAT112.469212.232812.84819.25928.97069.2705
CDK112.092411.680811.50279.51869.36778.8613
GNAI27.6727.28537.78484.99565.73935.8153
PIP4K2B10.07489.29949.60797.9157.33057.803
RPA210.783710.714410.64169.27439.45459.3044
BNIP313.110612.892813.126811.821511.830911.6011
MYBL211.169310.244510.84566.99787.93857.6942
CCDC85B9.20329.47128.97976.10976.40485.7463
DDB29.65079.91129.03477.03526.34356.8049
HADH10.863911.17510.78676.90524.90057.535
STMN111.677611.639711.7587.78547.55427.3276
PGM111.704211.647511.782310.273710.11210.0544
NET111.126711.100311.09848.94729.28089.3391
PAFAH1B311.09110.996311.03599.25928.88298.3493
G3BP110.0110.119510.41657.19767.75487.486
CDCA410.541910.569710.27577.40516.90956.6141
NUSAP111.301211.505311.55739.51999.33459.201
PXMP210.522810.755310.60359.218.75019.379
CHEK210.395610.135111.04788.68928.2828.5305
ADH512.606312.395712.79911.460411.142511.2004
BPHL9.45459.87289.46146.39366.73956.5351
AMDHD211.51811.688811.28627.46857.00486.5242
ACAT213.027313.057512.68959.710410.532310.891
PIN113.428913.620313.524511.838111.925212.2254
RPIA13.612413.563713.766712.1312.153312.336
RFC29.58319.12629.58677.58187.73667.6309
ADI110.600810.156910.54718.5959.08138.7241
TSPAN411.694711.576611.616510.422510.422510.1524
GPER18.83458.68328.91056.94386.84086.311
POLE29.19929.3549.16597.70987.17476.9297
SLC37A47.47237.59927.84645.31064.98484.9522
DLGAP511.185411.220411.46659.05648.01548.4112
FAM162A11.86212.21711.6349.498.64849.1588
CEP558.72468.46788.62136.80226.72556.7693
GLUL8.23398.37287.57732.4362.47852.4758
CTSA14.118414.275713.872311.907412.124111.6858
SUMO311.478411.247110.70838.96658.71068.6236
NREP5.95825.06195.44112.86223.34973.3437
IFITM211.40410.454211.0798.09497.9447.3063
GLB110.875410.074110.19727.89318.26818.0877
LANCL19.58779.63859.71257.5947.68377.8063
FIBP9.48959.31269.14868.15518.05247.93
UNG11.503611.184311.40097.88779.1228.8948
TK110.432110.118410.07098.06098.55188.5438
DHFR10.466410.24729.82918.33148.47148.1829
TOB110.615410.251810.62469.31738.77788.9518
RNASEH2A10.844910.816511.04849.23418.50768.0674
CYBA10.250810.324510.8147.76577.94448.2122
SPAG510.742210.424710.13927.50518.20078.6508
TMPO11.870112.209812.003810.208610.610110.2938
SKP212.484712.265112.87749.18829.3098.6171
NQO212.601212.583512.671510.801810.10710.5723
VRK19.6910.01319.92628.09258.41057.4701
TRIP1310.895810.590510.85498.28138.6327.8479
MYL6B13.289612.492812.77229.754110.370610.1138
GTSE110.107710.05059.42957.57897.69338.0003
POLA28.13327.70367.74356.31316.3666.5471
KIF119.87159.61199.66277.01927.59238.0372
KIF238.99599.64389.32847.33117.4167.804
SLC29A27.80758.16677.90986.73516.15196.2763
NUDT17.94067.28257.27385.64284.77715.1096
MGMT8.81038.74138.10237.00976.61356.817
SH3BGR5.3515.35875.45674.28843.86094.0955
RAD519.19889.18438.96856.61727.52877.3383
PRIM18.69498.66958.56296.31257.18586.9828
CDC25C8.05848.51818.19086.70046.09566.1634
PEBP114.627514.009114.459312.422910.982211.5589
GAMT10.17879.564110.05877.29797.48666.7403
PDZK18.7099.51698.40945.77554.34134.9732
SAC3D111.253811.124310.93889.1249.41178.7279
SPINK27.53587.22417.15395.06745.71295.1188
CENPF9.26989.37478.99827.28376.89436.9705
CD16413.297613.357313.658311.584411.901411.6786
C1S8.4138.07458.72746.32095.57275.4185
XPO112.380312.466812.804310.285410.088910.6711
CCNG110.879610.220911.00087.48528.45538.2078
DUT11.512411.590111.6619.431910.13249.1746
TUBB14.9921514.916112.816412.370212.5783
QDPR10.668111.395310.74788.11755.58026.7448
POLR2H10.833310.740610.79179.30579.14828.7386
AMACR8.24519.65188.39016.04925.05825.0598
LRP510.156810.413110.37728.80638.77689.1635
NSL110.122210.429110.33579.04948.98598.6062
PCYT211.353211.628811.48339.91189.47549.4193
BUB111.433111.249311.42419.4799.64988.9904
TTR10.717611.581911.24788.99059.0378.8896
SPC259.486710.00999.71146.82217.05037.6639
ABHD14A8.82538.97448.89846.95366.99977.1938
TPX213.685312.954813.939611.412210.892210.9818
BIN17.63467.43247.41855.86575.60045.3751
SIVA111.925211.276911.50739.85249.9829.99
KHK9.17098.8519.03077.58337.51667.1888
HSPA28.75999.13029.33645.76456.44445.68
ARL6IP112.749112.622213.067710.753111.336411.2645
MKI678.90458.34058.66697.11616.84766.8415
IFITM313.001513.621713.10649.051210.58138.9536
NME412.756912.693613.24818.84199.05988.8864
GTF2H511.538411.759411.49239.34489.29269.5333
ZBTB17.62148.19088.2826.57416.54836.5064
CHN28.90669.32729.1357.17867.4327.4813
KAZN13.596313.477413.256510.400211.177310.2699
OIP510.00279.87559.72027.45587.6687.8838
LGR511.173912.490612.68548.73149.23059.602
SRSF711.778911.265411.90749.91439.93489.5475
POLE9.44468.86558.51816.5586.67057.0728
RBBP412.068312.230212.292710.804310.471310.7077
MTCH213.88813.13713.054511.015611.158211.5337
MRPL1612.840113.176812.918210.836811.392211.4812
FKBP314.073313.231913.864611.791811.882311.9187
ECI214.613513.947514.310511.920910.465110.8428
ASF1B10.054410.067910.38277.56847.99737.3265
SPATA2011.394211.200410.70579.43229.43269.5934
SLC25A109.38438.9159.47127.72897.60877.7792
CARHSP111.75312.744612.014510.06159.20198.8505
SNX109.26089.75029.84696.88626.73126.0068
KANK28.19088.55678.12036.53156.52936.0651
TMEM14A9.83429.507710.59646.13086.27546.8931
SNRNP2513.238112.927712.99889.93879.894910.2714
SLC2A4RG10.28410.442811.09998.34738.29928.3657
HILPDA8.25278.09688.24216.47896.79866.3793
MRS211.464711.524911.833610.01910.01710.013
FZD49.37048.92718.95217.69357.77687.4836
RAB298.74818.97979.01027.21157.42567.5368
PAAF18.58968.57458.08296.98456.74986.6609
MIS18A9.4268.97578.94347.53517.72147.3493
GALNT119.19778.67078.86167.38677.2086.9894
SIRT58.12168.55428.09756.46965.80646.0639
MACROD110.444710.237710.46418.46557.97548.4064
ELP511.7112.1311.957810.305610.245610.1368
APOA213.653613.727413.506312.158112.302211.6531
DECR28.77968.85738.61597.48476.96696.9551
E2F86.7547.01277.034.26565.18445.0909
AUNIP7.67448.27418.36366.42966.55396.1956
RMND19.97210.314810.24768.55078.24028.556
NELFCD12.074912.774112.540310.468510.760110.6224
OSGEPL16.91876.52646.95725.3375.32835.0876
DNMT3B11.069810.515110.21018.52738.16248.3242
C1QTNF36.11576.57146.13753.71563.50553.8589
CDCA311.647512.440311.94359.47979.42679.4885
GINS211.199210.444310.62148.07068.81038.3134
CHPT113.286513.076112.910710.833310.301310.9499
SUB112.15912.396812.057110.820210.937910.9545
GLRX511.250511.37110.70618.64857.05418.5131
WRAP539.36599.10059.11547.97227.72448.006
HCFC1R19.77459.9059.88478.37078.16958.0448
PAH8.97819.08198.7617.23026.9617.6162
MAT1A7.74157.47637.63426.51236.41256.4107
MYH37.75857.77177.88956.20556.34886.3369
LEFTY17.53017.29427.28075.2135.66455.9721
F77.84687.54547.60786.25126.3236.1342

SMARCA4 transcriptional regulatory sub-network

The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network

ARTICLE: SMARCA4

[1] SMARCA4-Deficient Thoracic Sarcoma: A Case Report and Review of Literature.

[2] [SMARCA4-deficient thoracic tumors: A new entity].

[3] SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer.

[4] SMARCA4-deficient Thoracic Sarcomas: Clinicopathologic Study of 30 Cases With an Emphasis on Their Nosology and Differential Diagnoses.

[5] SMARCA4 mutations in KRAS-mutant lung adenocarcinoma: a multi-cohort analysis.

[6] The Genomic Landscape of SMARCA4 Alterations and Associations with Outcomes in Patients with Lung Cancer.

[7] SMARCA4-deficient thoracic sarcoma: a distinctive clinicopathological entity with undifferentiated rhabdoid morphology and aggressive behavior.

[8] Recurrent Loss of SMARCA4 in Sinonasal Teratocarcinosarcoma.

[9] SMARCA4-deficient Uterine Sarcoma and Undifferentiated Endometrial Carcinoma Are Distinct Clinicopathologic Entities.

[10] SMARCA4-deficient pulmonary adenocarcinoma: clinicopathological, immunohistochemical, and molecular characteristics of a novel aggressive neoplasm with a consistent TTF1(neg)/CK7(pos)/HepPar-1(pos) immunophenotype.

Transcription factor KEGG

The KEGG pathway of the TF in this TRN is shown below

hsa04714