ZNF207 transcriptional regulatory sub-network

The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network

NETWORK ID: CN357

In order to ensure the specificity of data, an ID index is built by the database itself, and each result corresponds to an ID.

CONDITION: AG-14361

IDBRD-K00615600
nameAG-14361
typeSmall molecule
molecular formulaC19H20N4O
molecular weight320.4
condition dose20 uM
condition time24 h
smilesCN(C)Cc1ccc(cc1)-c1nc2cccc3C(=O)NCCn1c23

CONDITION TYPE: trt_cp

Compound

CELL LINE: MCF7

Cell lines used for experiments

TRANSCRIPTION FACTOR: ZNF207

Transcription regulatory factors corresponding to this network

ARTICLE: AG-14361

[1] Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers.

[2] Resveratrol Attenuates Aβ25-35 Caused Neurotoxicity by Inducing Autophagy Through the TyrRS-PARP1-SIRT1 Signaling Pathway.

[3] PARP-1 inhibitor-AG14361 suppresses acute allograft rejection via stabilizing CD4+FoxP3+ regulatory T cells.

[4] PARP-1 inhibition influences the oxidative stress response of the human lens.

[5] Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361.

[6] Ionizing radiation-induced NF-kappaB activation requires PARP-1 function to confer radioresistance.

[7] Novel pathway of centrosome amplification that does not require DNA lesions.

[8] Exploiting the Achilles heel of cancer: the therapeutic potential of poly(ADP-ribose) polymerase inhibitors in BRCA2-defective cancer.

Differential expressed genes in this transcriptional regulatory sub-network

| logfc | > 0.45 and P < = 1e-5. If you want to view or download the data, you can click [expand]

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Symbolcontrolcontrolcontrolconditionconditionconditionconditionconditioncondition
PTPRH5.75236.05566.12916.56596.81496.82056.21566.56816.7887
ANGPTL23.08863.09992.65013.62493.78584.10723.46074.40994.4009
PTGDR5.09774.66874.60485.51715.32185.28185.58845.39355.3406
ZNF5574.87344.28694.7455.20665.43885.27275.21975.60665.6982
NFKBIA9.02548.8438.97949.3159.44269.70049.60299.55729.659
FOSL15.38435.65615.54456.56237.00597.14377.35736.52027.2385
NOTCH18.19298.14398.26498.91718.95478.82399.16148.98938.8888
MAPKAPK210.040110.991110.233911.047611.93311.577611.579612.336811.8549
PLCB38.9499.13039.27839.46459.54119.83199.95559.73769.7342
DPH27.58017.65227.35568.60588.87488.78898.82548.73098.8987
TRAPPC6A9.0068.96129.883310.805510.119110.048210.749910.700410.7122
CAMSAP29.27249.13349.488110.8839.96679.77339.90310.567310.316
TOMM348.75918.87298.54059.94619.50749.6759.53789.04599.2666
DDIT49.32539.21839.571910.670210.332810.121210.700410.766110.3209
STK2510.2099.919310.397211.152510.889911.033111.295211.255611.3517
MYC10.083110.11410.054111.643710.76811.058310.924311.369911.2665
LRPAP19.53789.48659.467710.413910.141310.621410.006110.008210.13
TCEA29.26299.22199.571910.26610.241510.108410.275710.567310.4653
FHL211.175811.481511.132713.464512.705412.812511.998112.666812.5373
TSTA37.32227.46617.24338.01898.68638.63698.50948.45368.3451
GAA8.26898.31078.13259.21729.2959.06969.59188.32399.104
DDB29.33769.35879.542610.22839.84939.69269.934110.393310.0795
NET19.86029.49959.865610.413910.587710.4310.483410.505510.4834
P4HTM9.56659.4429.9910.84410.84410.705611.155510.741910.861
GATA310.662310.871910.904212.039311.639511.698712.071211.840811.8648
RFX57.72397.79037.71758.90659.08518.99439.25338.91758.8626
EDEM17.64427.44177.83178.32588.00658.06028.32398.60988.4734
PPIF9.578210.02429.321311.750310.325911.560810.215110.954810.7579
DALRD37.58297.59497.73168.91228.56348.42928.10198.31368.8239
BTG24.16425.06386.21577.55128.15066.37777.84998.40637.7125
ESRRA8.83799.18469.04459.47099.8429.90099.43949.68099.7838
EIF2S19.07839.38679.353910.233310.213710.27410.027610.13999.9153
CHD48.15328.1748.19798.61188.6748.81029.17749.62289.3581
ITGA37.85177.35697.93778.55838.1288.91118.58188.93928.7879
PYGB10.445110.377810.536711.579611.479511.099811.380411.550210.8021
KRT1811.445811.970811.880213.904614.545714.545712.841213.784713.1304
JOSD17.43166.87917.38237.9337.83197.87647.53498.22838.0611
UBXN19.4279.38719.304210.140410.142510.04019.677710.202710.1811
IMPDH29.50669.2439.671710.30510.854910.009510.089110.457811.1535
GNL29.08958.7369.13279.620710.196510.12419.522810.53410.2808
SDC48.67059.29688.799411.536611.146610.24199.855511.24610.7255
SPINT18.29548.2337.99498.81489.41388.80088.76719.24838.687
CHST155.35855.07565.71557.63686.24296.3987.07017.69047.3447
ALDH1A36.00445.22295.73237.49757.36066.87946.0996.55826.8916
PDLIM77.40927.97137.71229.02229.19298.10498.70578.66328.5748
IL326.43745.99155.93637.84398.45957.47487.05667.99468.4409
SLC31A24.62995.36864.68335.74115.87215.7735.58775.89055.7439
ATP7B6.83936.27417.04077.29597.4277.58217.54948.0387.652
RAMP17.80857.11548.19598.31589.9389.03648.64129.04459.5949
PIGF10.10849.5249.667211.022110.73510.386410.523310.698510.4232
DNAJC47.95848.03457.59638.43598.7268.73868.3278.88518.5613
ISLR5.05165.16564.89377.37496.23425.8796.06777.04777.7224
ACTN111.21611.183611.351712.995312.556711.667212.181912.701512.0577
NDUFV110.708511.090410.988911.923311.517411.535411.567212.325811.6284
KRT79.93339.22468.409511.429712.329412.18199.767911.17411.3793
PHLDA211.778110.443310.941514.197613.388712.361112.187312.500113.1782
LAMA57.01318.08467.58698.62938.53528.32218.24278.58498.1465
PLAUR3.19372.98473.83774.1454.24034.30554.56524.28434.1149
ATP6V0D110.438111.38210.570412.057711.209211.499911.826611.704712.0525
AP2A28.39088.19648.47518.88929.20488.85819.58589.06759.5378
NEK95.39694.92095.50726.06356.58265.93365.90865.93335.951
SCRIB10.077210.50059.653511.323711.717611.998110.832111.714311.2538
DENND5A7.23486.93957.19438.38658.07168.57587.60127.79337.6542
TNPO19.06649.46399.21349.878610.0710.00689.57139.97610.1511
ZNF37.94018.10648.13488.87838.69188.83188.7219.00539.5399
PACS27.32456.96217.08428.05767.99687.54278.06778.28788.0053
GATAD16.50616.88196.97677.51357.89677.40637.94687.25437.5729
ARHGEF187.31937.46277.99668.45218.56888.68468.72018.81979.3026
ZFYVE265.56365.72435.97916.21096.27526.11236.4246.5096.6593
HSPA66.13635.37134.38816.91517.35567.0596.82426.66817.3795
NOP1611.887411.363211.847112.509412.527712.434912.502412.924112.4897
WDR439.469210.29210.041711.441511.053110.955810.627610.51410.6679
ZKSCAN16.0086.01335.21587.1677.53446.73486.77737.40746.947
NBPF106.04715.83525.78286.57316.47626.54716.9517.35946.8011
BCL65.74025.16465.11596.87596.77596.03846.20076.71376.7135
SFXN36.72596.89836.8797.267.73467.42547.86987.99647.6986
GSTK111.059710.565510.980612.527711.950112.108811.821812.130611.8771
FAM160B27.64978.04767.50878.78298.45258.11658.60698.6358.3435
MICAL18.53898.27438.74329.63489.30579.60989.52739.903710.1569
PRKRIP17.67697.83058.16178.16918.54398.46258.63788.75588.5785
DNAAF58.59518.80768.65329.23969.48729.33769.13999.63119.8029
IER510.35479.63389.599811.160210.942912.044811.24611.906111.4942
PUS79.20279.3869.98210.482311.095610.719210.554110.935910.8589
FBXL67.55837.78747.34828.80498.64868.34227.87268.47018.6154
SPHK16.35315.97915.86157.53336.88796.44196.74787.39547.0472
MICALL28.52748.64098.31139.55379.46119.36788.90839.75239.4286
ZNF2675.34265.45115.91746.50156.58396.22046.20986.17636.327
ZMAT34.65494.85314.61435.70975.48335.53625.31316.27675.6587
ENGASE7.08337.12757.15727.59487.81828.72157.99398.34477.8564
SLC25A3211.334711.31911.755912.831612.338411.826612.116312.121912.6432
SCLY8.42618.14068.01199.20919.37619.01598.97779.04249.314
RRN39.40239.05989.50339.860210.205710.226710.073610.47159.9216
PPP1R106.63576.6136.9847.18987.24647.41597.78227.30867.4358
FCGR2A4.41723.40874.12374.99954.7495.65025.44885.45965.8751
AMPD14.27044.07154.74595.05884.88824.69325.10845.2555.266
HBZ4.40254.06244.95065.31255.24944.92555.17695.65175.3126

ZNF207 transcriptional regulatory sub-network

The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network

ARTICLE: ZNF207

[1] A distinct isoform of ZNF207 controls self-renewal and pluripotency of human embryonic stem cells.

[2] Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia.

[3] ZNF207, a ubiquitously expressed zinc finger gene on chromosome 6p21.3.

[4] Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy.

[5] Integrative bioinformatics analysis reveals miR-494 and its target genes as predictive biomarkers of trastuzumab-resistant breast cancer.

[6] Oncogenic HER2 fusions in gastric cancer.

[7] Chemically Induced Hypoxia Enhances miRNA Functions in Breast Cancer.