NBN transcriptional regulatory sub-network
The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network
NETWORK ID: CN3976
In order to ensure the specificity of data, an ID index is built by the database itself, and each result corresponds to an ID.
CONDITION: triptolide
condition dose: 100 nM
condition time: 24 h
CONDITION TYPE: trt_cp
Compound
CELL LINE: MCF7
Cell lines used for experiments
TRANSCRIPTION FACTOR: NBN
Transcription regulatory factors corresponding to this network
Curated target protein/gene of this condition/drug
Protein target or gene target of this condition curated by previous studies and their associated KEGG pathways are shown below
| Target Gene | KEGG pathway |
|
RELA 
|
hsa05132 
|
Differential expressed genes in this transcriptional regulatory sub-network
| logfc | > 0.45 and P < = 1e-5. If you want to view or download the data, you can click [expand]
| Symbol | control | control | control | condition | condition | condition |
|---|---|---|---|---|---|---|
| EED | 8.5215 | 8.2213 | 8.7376 | 5.7302 | 5.7463 | 5.9002 |
| CEBPA | 6.4781 | 5.5282 | 5.7165 | 3.0017 | 3.373 | 3.2257 |
| CDK7 | 11.4903 | 10.6056 | 11.3516 | 9.3781 | 8.8017 | 8.1516 |
| HSPA8 | 11.4089 | 10.3841 | 11.2357 | 5.1519 | 5.8515 | 5.8651 |
| PDGFA | 7.5634 | 6.3468 | 7.231 | 4.5238 | 4.5768 | 4.9842 |
| TSKU | 6.7622 | 6.4489 | 8.2347 | 3.6562 | 3.7133 | 3.7829 |
| XBP1 | 12.202 | 10.8333 | 13.0382 | 6.874 | 9.0289 | 7.9449 |
| DNAJB1 | 10.3317 | 9.3594 | 9.5112 | 6.1403 | 6.2084 | 5.6412 |
| CCNA2 | 9.2364 | 9.1929 | 9.125 | 5.0419 | 5.9278 | 4.9255 |
| TMEM97 | 9.5644 | 9.8141 | 9.5469 | 6.4748 | 7.6377 | 6.8278 |
| YKT6 | 9.3253 | 8.7031 | 8.2347 | 5.9887 | 6.2371 | 6.6849 |
| RAD9A | 7.4608 | 6.9864 | 6.5553 | 4.4309 | 5.0324 | 5.2869 |
| MYC | 10.3317 | 8.9837 | 9.9196 | 6.1899 | 5.7627 | 6.089 |
| RAE1 | 11.9981 | 10.6201 | 11.3415 | 6.5483 | 7.4848 | 8.6968 |
| PLA2G15 | 6.3603 | 5.9509 | 6.3359 | 3.8378 | 4.6754 | 4.1034 |
| KEAP1 | 9.9528 | 10.0522 | 10.1945 | 8.3276 | 8.38 | 7.8256 |
| LBR | 7.9858 | 7.2454 | 7.9641 | 4.7175 | 5.5803 | 5.751 |
| RNMT | 6.5951 | 5.8664 | 7.1567 | 3.4756 | 3.602 | 3.9959 |
| ATP1B1 | 9.6084 | 10.2746 | 9.5469 | 6.8929 | 7.8007 | 7.9501 |
| POLG2 | 9.2421 | 8.6909 | 8.1122 | 5.7899 | 6.1484 | 6.6218 |
| PUF60 | 14.9429 | 14.5864 | 15 | 10.916 | 11.57 | 12.2409 |
| JMJD6 | 10.8333 | 9.9485 | 11.1694 | 6.2052 | 6.6549 | 6.9821 |
| SCAND1 | 12.1789 | 11.7222 | 11.7031 | 9.1879 | 10.1052 | 8.9563 |
| CANT1 | 13.0314 | 12.4652 | 12.5749 | 10.7941 | 10.2594 | 10.1582 |
| PRR7 | 9.4321 | 8.2874 | 9.3785 | 5.7194 | 6.457 | 6.1479 |
| CGRRF1 | 9.5749 | 8.9109 | 9.3043 | 6.7543 | 7.3502 | 7.1043 |
| KIF14 | 6.5718 | 6.4013 | 7.0229 | 3.8133 | 3.4028 | 4.8569 |
| GATA3 | 9.6841 | 7.4494 | 10.4531 | 3.8968 | 4.1559 | 4.541 |
| TIMM9 | 14.7854 | 13.5233 | 13.7771 | 8.5042 | 10.4531 | 9.177 |
| RNPS1 | 13.9014 | 15 | 14.3476 | 9.786 | 10.323 | 11.017 |
| CCNF | 7.8179 | 7.1792 | 7.1812 | 4.4619 | 5.0091 | 4.5876 |
| POLE2 | 9.1691 | 7.0489 | 8.6571 | 5.0464 | 5.2347 | 4.4025 |
| SNX11 | 6.8191 | 5.2951 | 5.9937 | 2.7897 | 3.6252 | 3.0728 |
| DLGAP5 | 9.4921 | 9.955 | 10.0952 | 6.3078 | 6.157 | 7.4662 |
| AREL1 | 8.3159 | 8.0927 | 8.0664 | 5.4983 | 5.7815 | 6.3294 |
| SCAF8 | 7.7326 | 7.6646 | 7.4356 | 4.5042 | 5.1895 | 4.5255 |
| KAT7 | 7.9396 | 7.0032 | 8.2799 | 4.693 | 5.3865 | 5.4413 |
| ZNF146 | 9.3693 | 10.2013 | 10.0558 | 6.8057 | 7.4026 | 7.899 |
| RAF1 | 9.1266 | 7.5903 | 8.5444 | 6.0201 | 6.2168 | 6.0231 |
| TMX4 | 10.2799 | 10.0905 | 9.5205 | 5.3759 | 6.7824 | 6.7625 |
| DDX39A | 11.9313 | 11.83 | 11.7334 | 9.5472 | 8.7443 | 8.6909 |
| MARCKS | 7.0681 | 7.0105 | 7.7648 | 3.5405 | 4.8399 | 3.5307 |
| ADNP | 8.5182 | 9.361 | 8.9608 | 5.9825 | 6.1721 | 6.0848 |
| WDR82 | 8.8857 | 8.2173 | 8.6543 | 5.3765 | 6.4634 | 6.0163 |
| PLK2 | 11.4671 | 11.346 | 11.3928 | 5.8425 | 8.604 | 6.0094 |
| VEZF1 | 9.4181 | 9.3708 | 9.5578 | 5.9976 | 7.2403 | 6.8113 |
| NOTCH2 | 4.8555 | 5.5985 | 5.6345 | 2.2383 | 2.5469 | 2.8361 |
| SNRPB2 | 11.8431 | 11.5959 | 11.454 | 9.5211 | 9.3191 | 10.0414 |
| CHTOP | 8.2621 | 8.8727 | 7.9776 | 5.7463 | 6.3257 | 6.7123 |
| TFIP11 | 8.8338 | 9.2769 | 8.7507 | 7.1929 | 7.4533 | 6.9248 |
| U2AF1 | 12.355 | 12.567 | 12.6909 | 10.183 | 10.4988 | 10.7757 |
| MGAT2 | 9.2209 | 10.6607 | 9.4739 | 6.4592 | 7.3294 | 6.0165 |
| EEF1D | 10.9538 | 10.1276 | 11.0119 | 7.9936 | 8.6353 | 7.8984 |
| WTAP | 9.5889 | 9.3637 | 8.6725 | 5.9893 | 7.1227 | 6.4794 |
| SRP54 | 9.0515 | 7.8649 | 9.2587 | 6.2127 | 6.3816 | 6.2712 |
| COIL | 9.7943 | 9.7218 | 9.9781 | 5.9543 | 7.3217 | 7.3931 |
| ZNF263 | 8.5441 | 8.483 | 8.2892 | 6.1149 | 6.8128 | 6.4106 |
| PPRC1 | 8.5202 | 8.7199 | 8.4973 | 6.9532 | 6.8829 | 7.2415 |
| RBM14 | 8.5918 | 7.5357 | 8.8638 | 5.3728 | 5.7354 | 6.2011 |
| RUNX3 | 5.1379 | 5.5603 | 5.0513 | 3.5924 | 3.3914 | 3.7621 |
| BRPF1 | 7.3897 | 7.2774 | 7.4572 | 4.9299 | 5.3773 | 5.727 |
| PPM1D | 11.4009 | 9.4904 | 10.3959 | 6.6363 | 7.1235 | 7.8614 |
| IDI1 | 10.9756 | 11.1355 | 11.6945 | 8.4382 | 9.2248 | 9.458 |
| DUSP2 | 5.7723 | 6.1149 | 5.3793 | 4.1809 | 3.5843 | 3.8705 |
| GABRP | 11.7584 | 11.557 | 11.4601 | 9.1961 | 8.5309 | 7.003 |
| TCN1 | 8.1814 | 7.5948 | 8.1005 | 0.8432 | 3.362 | 2.5109 |
| GEMIN4 | 9.8939 | 9.2737 | 9.6583 | 7.6721 | 7.6826 | 7.696 |
| FAM50B | 7.7498 | 8.1671 | 7.9276 | 5.6468 | 6.3286 | 5.8455 |
| RARRES1 | 4.3741 | 2.7467 | 4.2227 | 0.6341 | 0.9399 | 0.6341 |
| SIX2 | 6.7562 | 6.8021 | 7.5855 | 4.7445 | 4.1684 | 5.1357 |
| KAT5 | 8.003 | 8.3298 | 7.7624 | 5.5159 | 6.3646 | 5.7081 |
| MAPK6 | 10.403 | 9.8876 | 10.0346 | 7.0284 | 6.9879 | 7.1909 |
| SNUPN | 6.6284 | 5.7427 | 6.6682 | 3.8433 | 4.2878 | 3.8084 |
| URM1 | 10.9186 | 10.2666 | 10.4294 | 8.1236 | 8.5588 | 8.7199 |
| KDM2A | 7.263 | 6.9166 | 7.2014 | 4.5834 | 5.5461 | 5.461 |
| KRT7 | 9.7897 | 11.3561 | 10.4653 | 3.6962 | 5.2695 | 6.3556 |
| PATZ1 | 8.4585 | 9.0611 | 8.2127 | 5.9516 | 6.3041 | 5.8944 |
| SLC19A2 | 9.0104 | 7.3959 | 7.6167 | 3.9314 | 4.7348 | 4.7749 |
| FRAT2 | 7.7267 | 6.6195 | 7.517 | 5.1059 | 4.5181 | 5.064 |
| ZNF410 | 8.9016 | 8.2493 | 8.9506 | 5.3247 | 6.3876 | 6.6371 |
| APEX1 | 15 | 15 | 15 | 13.0694 | 12.9548 | 12.0486 |
| HAUS3 | 8.8896 | 8.5441 | 8.3008 | 6.2697 | 6.624 | 7.1187 |
| PTGES | 4.755 | 4.5504 | 3.8922 | 1.0726 | 1.0726 | 1.0461 |
| WDR37 | 6.7401 | 6.6038 | 6.8902 | 4.3001 | 4.5023 | 4.4212 |
| FBL | 12.8797 | 13.5063 | 12.6319 | 10.1697 | 11.0502 | 10.4238 |
| KPNA2 | 13.7115 | 13.8423 | 13.9699 | 10.4988 | 11.6245 | 12.1019 |
| EIF4A1 | 14.8025 | 14.1983 | 15 | 12.0417 | 13.0233 | 12.3151 |
| EIF4B | 9.476 | 8.3614 | 8.9988 | 5.5669 | 6.9661 | 6.2734 |
| TOP2B | 7.7971 | 6.4686 | 7.6059 | 4.3344 | 4.8931 | 5.124 |
| CHMP7 | 8.1961 | 8.2401 | 8.639 | 5.2222 | 6.0997 | 6.5812 |
| FAM102A | 8.5574 | 9.0909 | 7.7116 | 5.4662 | 6.1871 | 5.9401 |
| CENPB | 9.497 | 9.4977 | 8.8799 | 7.1697 | 7.3483 | 7.3842 |
| RNF4 | 9.9988 | 10.4021 | 10.3986 | 7.9088 | 8.7095 | 8.3609 |
| RCHY1 | 6.955 | 5.4805 | 6.642 | 3.834 | 3.998 | 3.9886 |
| YLPM1 | 7.4163 | 7.8744 | 8.1245 | 5.2673 | 6.159 | 5.82 |
| TSPYL5 | 7.838 | 9.3821 | 7.2395 | 4.0315 | 4.0594 | 4.5624 |
| ZNF473 | 6.2942 | 6.3379 | 6.5559 | 4.8196 | 4.6919 | 4.8639 |
| SNRPB | 11.9188 | 11.3666 | 12.6942 | 8.5932 | 9.6177 | 9.8244 |
| METTL18 | 7.3349 | 7.5778 | 7.7894 | 5.7417 | 6.1389 | 5.772 |
| NGDN | 11.6859 | 11.0044 | 11.2656 | 8.4865 | 9.1539 | 8.1375 |
| SLC25A16 | 7.4555 | 7.6835 | 7.624 | 5.9502 | 6.0856 | 6.1596 |
| SRSF7 | 10.3186 | 10.2736 | 11.5429 | 6.9983 | 8.3942 | 8.0219 |
| WDR43 | 10.531 | 10.0012 | 10.1329 | 8.3476 | 7.6671 | 7.9466 |
| RIF1 | 7.9836 | 7.4771 | 7.9969 | 5.6518 | 5.7281 | 5.6097 |
| BRMS1 | 9.1215 | 8.693 | 8.7751 | 7.2504 | 7.4268 | 7.2766 |
| SEC16A | 7.9727 | 7.8882 | 8.3696 | 5.1148 | 6.298 | 5.9388 |
| SNX5 | 9.2115 | 9.1146 | 9.759 | 6.8776 | 7.4685 | 7.7805 |
| PRC1 | 8.9554 | 8.3614 | 8.2937 | 5.5989 | 5.6045 | 5.9674 |
| PRPF38B | 8.1237 | 8.105 | 8.0361 | 6.5158 | 6.4714 | 6.4513 |
| UBP1 | 9.5223 | 9.7246 | 9.9851 | 6.5638 | 7.883 | 7.4689 |
| NOL6 | 7.285 | 7.5643 | 7.7433 | 5.9022 | 6.0287 | 5.5241 |
| ATG101 | 9.5863 | 9.2038 | 8.4797 | 6.5257 | 7.342 | 6.8158 |
| GTPBP4 | 10.6355 | 11.5689 | 11.434 | 8.4166 | 9.2407 | 8.8704 |
| TACC3 | 9.4408 | 9.734 | 9.1906 | 7.3626 | 7.6414 | 7.6498 |
| TRIAP1 | 11.8598 | 11.5259 | 11.5147 | 8.7917 | 10.0714 | 9.5906 |
| TFB2M | 10.2122 | 9.7375 | 9.6436 | 6.918 | 6.8391 | 6.9889 |
| IER5 | 10.8051 | 9.2852 | 9.5982 | 7.5707 | 6.7927 | 7.5864 |
| EIF4ENIF1 | 7.0759 | 7.1723 | 6.9365 | 5.2908 | 5.7436 | 5.3847 |
| NXT1 | 9.757 | 9.1131 | 9.6254 | 5.7591 | 7.1352 | 6.9004 |
| RRP15 | 11.1317 | 10.3677 | 11.3543 | 8.2477 | 8.7358 | 7.9459 |
| HSPA14 | 9.104 | 8.901 | 9.4619 | 7.0671 | 7.3725 | 6.0978 |
| RBM15 | 7.1283 | 7.1731 | 6.9795 | 4.852 | 4.737 | 4.9279 |
| BOLA1 | 8.2817 | 7.845 | 8.2486 | 6.2017 | 6.0977 | 6.677 |
| SNIP1 | 7.4593 | 7.0752 | 7.8697 | 5.4531 | 5.0832 | 5.3925 |
| GIN1 | 6.8081 | 6.6719 | 6.5766 | 5.0034 | 5.3082 | 4.6075 |
| TDP1 | 7.0231 | 6.1938 | 6.6655 | 5.0497 | 4.6481 | 4.7502 |
| RBM23 | 8.7987 | 9.005 | 8.68 | 6.2006 | 6.9505 | 5.9168 |
| LTBP3 | 7.5826 | 6.7167 | 6.6561 | 3.3289 | 4.7912 | 4.4855 |
| PRPF18 | 7.7552 | 7.3784 | 7.7221 | 5.7698 | 5.9759 | 5.8779 |
| IMP3 | 9.6211 | 10.0602 | 9.7201 | 6.0194 | 6.6964 | 6.1539 |
| YTHDF3 | 7.4146 | 7.6652 | 7.3609 | 5.0084 | 5.0156 | 5.5908 |
| KANSL2 | 9.2587 | 8.8366 | 8.1299 | 6.1037 | 5.9949 | 6.8402 |
| CENPN | 8.6126 | 7.2667 | 7.4266 | 5.6938 | 5.3127 | 5.2168 |
| CSTF1 | 9.0913 | 9.1255 | 8.8199 | 7.5809 | 7.2638 | 7.3024 |
NBN transcriptional regulatory sub-network
The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network
ARTICLE: NBN
[1] Inherited NBN Mutations and Prostate Cancer Risk and Survival.
[2] NBN Gene Analysis and it's Impact on Breast Cancer.
[3] Nbn-Mre11 interaction is required for tumor suppression and genomic integrity.
[5] NBN-embedded Polycyclic Aromatic Hydrocarbons Containing Pentagonal and Heptagonal Rings.
[6] On-Surface Synthesis of NBN-Doped Zigzag-Edged Graphene Nanoribbons.
[7] GaN/NbN epitaxial semiconductor/superconductor heterostructures.
[8] Neuroscience-based nomenclature (NbN).
[9] Mutations in ATM, NBN and BRCA2 predispose to aggressive prostate cancer in Poland.
Transcription factor KEGG
The KEGG pathway of the TF in this TRN is shown below
hsa03440
