SNAPC1 transcriptional regulatory sub-network

The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network

NETWORK ID: CN5104

In order to ensure the specificity of data, an ID index is built by the database itself, and each result corresponds to an ID.

CONDITION: CGP-60474

IDBRD-K79090631
nameCGP-60474
typeSmall molecule
molecular formulaC18H18ClN5O
molecular weight355.8
condition dose1 uM
condition time24 h
smilesOCCCNc1cc(ccn1)-c1ccnc(Nc2cccc(Cl)c2)n1

CONDITION TYPE: trt_cp

Compound

CELL LINE: MCF10A

Cell lines used for experiments

TRANSCRIPTION FACTOR: SNAPC1

Transcription regulatory factors corresponding to this network

ARTICLE: CGP-60474

[1] LINCS L1000 dataset-based repositioning of CGP-60474 as a highly potent anti-endotoxemic agent.

[2] Drug candidate identification based on gene expression of treated cells using tensor decomposition-based unsupervised feature extraction for large-scale data.

[3] A new advanced in silico drug discovery method for novel coronavirus (SARS-CoV-2) with tensor decomposition-based unsupervised feature extraction.

[4] Novel and efficient access to phenylamino-pyrimidine type protein kinase C inhibitors utilizing a Negishi cross-coupling strategy.

[5] Comprehensive Analysis Identifies Potential Ferroptosis-Associated mRNA Therapeutic Targets in Ovarian Cancer.

Curated target protein/gene of this condition/drug

Protein target or gene target of this condition curated by previous studies and their associated KEGG pathways are shown below

Target Gene KEGG pathway

CDK1

hsa04114

CDK2

hsa05160

Differential expressed genes in this transcriptional regulatory sub-network

| logfc | > 0.45 and P < = 1e-5. If you want to view or download the data, you can click [expand]

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Symbolcontrolcontrolcontrolconditioncondition
CLTC9.78889.96999.77213.57024.6394
CRK9.39399.63789.30995.97085.6927
HSPA811.30511.420711.4774.40614.4682
PCNA13.642313.978613.56736.54287.4545
SUV39H17.52948.15937.71483.88423.8433
DUSP611.325511.801911.78265.90126.3688
CDC25B12.714412.209112.54127.40567.8429
MAPKAPK211.921111.65411.69728.418.6204
HSPA1A12.59212.13911.83698.58518.5349
CCNA210.146610.54599.95534.3993.7461
ATMIN6.44756.84116.22762.4773.0971
OXSR18.5268.85518.49594.58835.0561
NUP628.25978.14277.82884.43143.164
MYC12.742212.815612.73168.03067.018
EGFR8.68858.83828.46945.67684.8737
RGS29.629310.19089.72784.47354.4305
SCYL35.2815.07765.17972.80072.8279
POLG27.75817.43637.36553.95164.5791
JMJD611.279311.046411.14276.48856.9896
NUP8510.812510.420810.93067.23367.1695
PARP28.54328.71698.45585.09215.0849
CCNB211.796511.84411.67878.2448.2921
JADE28.44897.9677.95332.70443.0024
POLE27.97537.80928.08323.74643.6265
KIF20A9.91849.729.49835.61025.3897
ZC3H47.70627.65917.44.04824.545
NOP5614.604414.604414.15849.44039.3552
AMD19.29179.7348.93995.18464.8632
HNRNPF10.432110.672510.05126.54075.5995
PUM28.37558.24277.95244.58935.2578
CDC1239.41658.67189.12645.04013.7403
ADNP8.51059.22178.72814.33224.9245
WDR829.64879.98859.29745.81415.0138
VEZF17.32697.1937.1654.65224.6671
TAF157.68527.61497.5864.93244.7501
BMS110.176210.409310.01877.51517.3479
MGAT29.51639.95979.67875.31816.0134
COIL8.08247.91327.88934.77274.9493
PI37.50667.14957.154.16824.0345
CSTF37.68077.1537.58874.41034.3334
CKS210.466211.02249.8416.19666.6024
RBM148.59999.48139.17814.57744.8595
TMEM2438.85568.7318.98616.01885.7603
KIF238.96198.91618.88936.26455.6843
EXOSC98.03078.42118.52175.16595.564
SAC3D18.79589.15268.75276.07055.3227
HSPA4L9.5879.86149.74845.23564.462
TFCP28.30638.27128.10445.64385.7214
POLR3D7.77887.84427.88125.40144.8491
G3BP29.5319.73639.12286.32255.7635
SEPHS19.10098.73249.11965.32285.2297
TNFRSF10B11.286610.891311.5176.01174.7327
UAP19.685210.26239.18055.38185.3855
PHF209.14448.33058.05914.6544.3177
PATZ16.97776.59176.76024.06974.2105
AHNAK9.65579.33889.04715.81946.107
ACACA7.71127.62617.89435.17394.7809
KRT1710.538311.816611.8856.71326.4042
CHMP78.77658.60358.44785.07444.6789
NCAPH9.68219.71669.50297.17197.4487
DUSP78.58839.51688.89434.5194.7541
SRSF79.58649.53799.69055.7276.2819
WDR4310.058410.057610.39867.48317.7073
RIF18.43418.95228.23585.40595.1418
ARHGEF109.26018.45588.37834.75854.5689
WAC7.82967.57297.51864.8984.4446
RPS269.908710.48259.87566.26786.5403
SYNCRIP9.44379.4239.37316.77166.0879
TRAPPC48.58598.71238.34925.15215.8627
PRC19.47259.04428.43394.98675.0626
GGNBP27.83698.48878.38795.2714.8885
UBP18.36998.45928.30955.42895.261
NOL89.36739.40789.07226.52396.8326
SAV18.5358.56088.67565.05834.7685
EIF4ENIF16.88677.39037.28164.6054.2278
CWC256.38476.27646.35254.2293.9122
NXT19.15268.74148.91924.92145.4697
ZBTB7A8.50858.53828.56196.12946.3111
UBAP29.03299.76279.18565.86625.9193
MEPCE5.36815.54155.35123.20583.1431
ARPC5L9.73489.78499.85496.52756.5762
ASB67.16377.44127.45664.81315.0427
SPDL18.71618.16048.22925.31234.8967
IMP39.98179.57539.91945.31675.9014
SETD58.99898.33478.53613.91214.076
KANSL28.44028.58128.32736.20036.0037

SNAPC1 transcriptional regulatory sub-network

The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network

ARTICLE: SNAPC1

[1] Requirement for SNAPC1 in transcriptional responsiveness to diverse extracellular signals.

[2] Regulation of RNA polymerase III transcription during transformation of human IMR90 fibroblasts with defined genetic elements.

[3] Onconase responsive genes in human mesothelioma cells: implications for an RNA damaging therapeutic agent.

[4] Identification of differentially expressed genes in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomas.

[5] Mapping of a chromosome 12 region associated with airway hyperresponsiveness in a recombinant congenic mouse strain and selection of potential candidate genes by expression and sequence variation analyses.

[6] Rare protein-coding variants implicate genes involved in risk of suicide death.

[7] The unorthodox SNAP50 zinc finger domain contributes to cooperative promoter recognition by human SNAPC.

Transcription factor KEGG

The KEGG pathway of the TF in this TRN is shown below