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ZNF711 transcriptional regulatory sub-network

The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network

NETWORK ID: CN6787

In order to ensure the specificity of data, an ID index is built by the database itself, and each result corresponds to an ID.

CONDITION: BMS-387032

ID	BRD-K43389698
name	BMS-387032
type	Small molecule
molecular formula	C17H24N4O2S2
molecular weight	380.5
condition dose	1.11 um
condition time	24 h
smiles	CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1

CONDITION TYPE: trt_cp

Compound

CELL LINE: MCF7

Cell lines used for experiments

TRANSCRIPTION FACTOR: ZNF711

Transcription regulatory factors corresponding to this network

ARTICLE: BMS-387032

[1] Overview of CDK9 as a target in cancer research.

[2] Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.

[3] Cyclin-dependent protein kinase inhibitors including palbociclib as anticancer drugs.

[4] Small-molecule cyclin-dependent kinase modulators.

[5] Transcriptional inhibition by CDK7/9 inhibitor SNS-032 abrogates oncogene addiction and reduces liver metastasis in uveal melanoma.

[6] P-glycoprotein plays a role in the oral absorption of BMS-387032, a potent cyclin-dependent kinase 2 inhibitor, in rats.

[7] Gateways to clinical trials.

[8] The cyclin-dependent kinase 2 inhibitor down-regulates interleukin-1beta-mediated induction of cyclooxygenase-2 expression in human lung carcinoma cells.

Curated target protein/gene of this condition/drug

Protein target or gene target of this condition curated by previous studies and their associated KEGG pathways are shown below

Target Gene	KEGG pathway
CDK2	hsa05166
CDK7	hsa03420
CDK9

Differential expressed genes in this transcriptional regulatory sub-network

| logfc | > 0.45 and P < = 1e-5. If you want to view or download the data, you can click [expand]

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Symbol	control	control	control	condition	condition	condition	condition
TIMM9	12.4934	12.4228	12.2547	8.9739	8.1776	8.4255	8.5911
CMC2	11.3109	11.2885	12.729	8.4545	9.1715	8.628	9.2963
GID8	10.9122	11.3379	11.3953	9.6303	9.5033	9.4108	9.7323
ZDHHC7	8.8081	9.1606	8.9798	6.2238	5.9675	6.1285	6.358
SUV39H1	6.9762	6.8203	7.5113	4.6832	4.5912	5.4294	5.0616
RBM15	8.6307	8.0618	8.1585	5.2621	5.341	5.3584	5.7943
SNX11	7.4219	7.25	7.7213	5.341	4.6936	4.1795	3.9466
BCAS3	12.1342	12.554	12.8241	10.366	9.2166	9.3917	8.8036
ARPC5L	10.7446	10.8431	10.5501	7.91	8.8366	8.2479	8.2969
TRIM8	8.0042	7.9944	8.1366	6.2498	6.2962	6.751	6.3788
SLIRP	12.2557	12.3995	13.123	9.9099	8.8004	10.4446	9.7707
TSPYL1	8.2063	7.5212	8.3559	6.1122	5.5245	6.1303	5.5575
IMP3	9.5733	9.4128	9.4337	7.1138	6.9117	6.6651	7.6057
YTHDF1	9.064	9.4317	9.2162	5.805	4.8976	5.184	6.2483
NOL11	13.4192	13.5565	12.948	10.4185	10.8327	10.8102	11.5787
RACGAP1	9.9468	9.5096	10.3045	7.6366	7.813	7.6002	8.1201
GDI2	10.6981	10.9388	11.3552	9.3919	9.0594	9.2044	9.4355
KHDRBS1	9.8121	9.6268	9.6902	8.1895	7.8576	7.8558	8.2899
ZNF146	10.7112	10.2541	10.3966	8.3393	8.6607	8.2939	7.2196
RNPS1	12.7797	13.0783	13.2649	10.8567	9.8596	10.6007	11.019
USP22	12.007	12.9833	12.8321	9.8361	9.4347	9.7291	9.4127
CLTC	13.2093	13.6331	13.576	11.1077	10.4356	10.8367	9.9077
DNAJB1	10.2182	10.9535	11.4449	7.1453	7.0193	6.7604	7.1028
XBP1	13.2979	13.1247	13.2206	9.1539	7.6436	8.6255	7.6081
HSPA1A	11.9686	12.5942	12.7897	10.0338	9.392	9.7925	8.8981
IST1	11.0661	11.1255	11.2105	8.8493	8.9526	9.3312	8.5846
DNAJA1	11.2426	12.1493	11.7849	7.8458	7.7885	7.7417	9.4785
SEPHS2	10.255	10.6119	10.7989	8.8512	8.5812	8.7397	8.6762
PSMA7	14.3732	14.7887	15	12.277	12.1545	12.6749	12.4451
AMD1	8.6805	7.7419	8.7048	5.264	5.5528	5.8576	4.576
RAF1	8.6378	9.5509	9.6855	6.6777	6.7133	6.5454	7.2422
ANP32B	11.9784	11.9312	11.448	9.7521	10.3649	9.3633	9.6905
HNRNPF	9.8077	10.5545	10.2409	7.8799	7.9162	7.8322	8.6593
DHX15	11.4238	11.1538	11.0413	9.4171	8.4713	9.1885	8.6893
SOX4	10.1986	10.1724	9.8034	7.7872	6.8813	7.4702	7.2906
USP7	7.7301	7.6315	7.8702	5.6872	4.3816	5.0637	4.4441
NFKBIA	10.5256	10.6453	10.9968	9.1095	8.0408	8.0032	7.9322
PSMA3	12.6462	12.1467	12.5708	10.656	10.4753	10.1338	10.0007
SNW1	9.1137	9.3631	9.5791	7.485	6.6498	6.9637	7.5539
SFPQ	9.5008	9.6053	10.136	7.2447	6.7018	6.8108	7.7048
PSMC6	12.7295	12.8225	13.1436	10.7582	10.8334	10.9311	10.0214
CDC123	9.3051	9.3548	9.6746	7.197	6.979	7.3686	7.2778
MTHFD2	12.0507	12.0605	12.0085	9.9287	9.4679	9.7217	10.5376
NET1	11.4076	11.3866	11.5032	6.8858	6.9963	7.4943	7.3748
CDC25B	11.6367	12.3561	12.2955	9.9494	9.9912	9.4701	9.2626
ATMIN	8.9802	8.9092	9.164	4.7069	4.1277	3.8805	4.4177
UBE4A	9.7405	10.1686	9.5202	7.3477	7.5635	7.0781	6.4725
SLC39A6	12.4914	13.2148	14.1505	10.0019	9.1167	9.6992	8.7216
AIMP2	9.1503	9.1309	9.2356	7.3482	7.3975	7.3306	7.6206
NUP62	9.0983	9.8186	9.4104	5.4375	5.4718	4.7716	3.8209
CHERP	8.8281	8.7298	9.5196	6.4412	5.5723	5.9571	6.5472
PRPF3	9.5584	9.2721	9.111	6.8398	7.0175	7.6328	7.6843
PSMD12	13.8512	14.5043	13.7873	10.6903	10.6675	11.4849	11.1468
ABCF3	8.5568	9.4604	10.1677	4.862	4.0862	4.1554	6.2919
TIAL1	10.694	10.0195	10.569	8.6934	8.4289	8.3741	8.4835
KEAP1	10.1986	10.4635	10.7924	8.2266	7.4242	7.8132	8.5382
CYP1B1	11.3469	11.2122	11.2157	5.8957	5.8022	4.7116	3.2472
VAPB	9.2098	9.8099	10.2826	7.8028	7.9036	7.7694	7.8188
NRIP1	11.2115	11.5686	11.1139	8.1039	6.1299	6.8677	8.1073
DPM1	10.7984	10.1354	10.8434	8.809	8.6192	8.8293	8.9352
TOB1	10.5515	9.7334	10.1489	7.737	6.3418	6.3743	7.2903
PSMD6	14.349	14.2165	14.9078	11.5731	11.9316	10.8827	10.88
SHOC2	7.3462	6.7111	7.5121	4.5896	4.2098	4.526	3.7153
ZMYM2	10.413	10.5539	10.6007	7.8498	7.3788	7.5405	7.7808
CDC20	11.7546	12.6606	12.5013	8.9918	8.3823	8.6532	8.8184
NBN	10.7067	10.4087	10.9128	8.8963	8.6407	8.7799	9.0963
UBE2C	11.0273	10.9186	11.3032	7.2104	6.2557	6.5429	7.8964
BCAS2	11.4478	11.0955	11.0082	9.2597	8.6838	9.2804	8.5875
KIF2A	10.1449	10.1377	9.6376	8.0921	8.287	7.7352	8.09
MGAT2	9.2216	9.5091	9.9914	5.6899	5.8678	6.0792	5.0849
SCAF8	7.8965	7.6741	8.1452	5.8936	5.0059	5.7386	5.6929
EZH2	8.875	9.3002	8.4905	6.7638	7.0193	6.9726	6.4285
RNF6	10.3421	9.4053	9.3541	7.9751	6.7153	7.1466	7.0964
PSMG1	11.1077	10.8433	11.215	8.6412	8.1704	8.1018	9.1013
TMPO	11.2017	10.7208	10.7009	8.7054	8.9552	9.0371	9.1418
TMEM11	9.9717	9.3589	10.2983	7.9886	7.603	7.41	7.6738
MED1	7.4268	7.4507	8.2782	5.5118	5.4585	5.7775	5.8291
TRAPPC3	10.4314	10.054	10.2718	8.4382	8.1614	7.8801	8.4352
SRP54	9.703	9.2606	9.8421	7.3834	7.6124	6.8738	7.6335
COIL	9.5893	8.5716	8.9493	6.8756	7.1803	7.0794	7.1243
ZNF217	10.6928	10.8636	11.4052	9.3343	8.136	8.7826	8.0459
TDG	11.0521	11.8753	11.9335	9.1733	8.8345	7.8584	9.4153
DLGAP5	9.3291	9.6028	9.8323	8.026	6.6894	7.3661	7.2662
FUT8	10.9546	10.8978	10.725	8.4463	8.8015	8.9182	9.2397
RABGAP1	8.0754	8.6424	8.5407	6.5575	6.297	6.1161	6.6504
TSC22D2	10.1707	10.7866	10.4153	7.8368	8.0741	7.8442	8.1039
RBM14	8.618	9.2235	9.6279	6.9805	5.9291	5.9573	6.2317
DBF4	9.1985	8.7362	9.2521	7.0625	6.6227	7.4359	6.4592
PPM1D	10.8061	10.9685	10.6777	7.5606	8.1591	8.6888	7.6417
IDI1	11.3413	11.7813	11.2179	7.9169	7.5451	7.8798	8.2771
ZBTB11	8.5682	8.8446	8.9406	6.5638	6.5214	7.1792	6.9945
TFF1	13.0185	14.6917	15	8.7269	8.3237	8.7113	7.5359
LSM6	7.5069	7.3033	7.2507	4.8326	5.2228	5.9255	5.4707
TFAP2C	12.7711	13.1082	12.1045	8.615	9.1758	9.1684	9.7193
HNRNPA2B1	12.6237	13.0969	13.1613	11.1101	10.7642	10.906	11.3979
KLK11	9.0231	8.4313	8.567	5.4462	4.5737	4.9066	5.8833
GREB1	12.1919	11.554	11.153	7.2226	9.389	7.654	7.4359
POLE2	7.6105	7.0648	7.3994	4.79	5.0881	4.9551	4.5602
GABPB1	10.3565	9.8898	10.2359	8.3343	7.8776	8.1259	7.9699
LY6D	5.396	4.7263	5.4164	3.3858	3.2258	2.643	2.7307
MAPK6	10.7388	10.4858	11.9484	7.2434	6.7859	6.6021	7.8
RPL36AL	12.0364	11.6704	12.6812	9.3325	8.6323	9.2438	8.6327
HSPA8	11.3018	11.9191	11.8812	6.8129	6.2315	6.3092	6.8398
TOP1	10.7365	11.5598	11.0379	9.2581	9.1976	9.1449	9.1556
DYRK1A	6.7715	6.8619	7.5816	5.1194	4.4808	4.2949	4.8067
RAB5A	8.6647	8.3268	9.2181	6.5363	5.9405	6.2561	5.8175
GLOD4	9.8475	9.9008	9.9959	7.4414	7.0193	7.5853	8.3675
CDKN1B	11.9184	11.7212	11.6188	8.3803	8.316	8.1568	9.2364
SFN	8.6928	9.3399	9.3324	4.79	6.0305	5.2412	3.184
UTP3	8.9064	8.7376	9.1775	5.7596	5.6906	6.1646	6.7687
GATA3	11.2728	11.0096	11.137	7.3949	6.8153	7.7023	7.0214
CDKN3	9.6796	10.1446	10.7704	7.4264	6.9424	7.3502	7.7401
RIT1	6.7946	7.031	6.6827	5.0881	4.4287	5.1087	5.0594
PUF60	12.8289	13.2498	13.6739	10.8567	10.1688	10.6585	10.8889
GYG1	12.3013	11.9637	12.1636	9.4103	10.0913	9.5358	10.3463
RAE1	11.6163	11.5518	11.6747	8.5568	6.4679	7.4943	8.5677
RET	10.9286	11.3827	11.1371	9.4552	8.4304	8.0759	8.4306
MIOS	6.9275	7.199	6.8299	5.2756	5.3912	5.1773	4.7696
KPNA2	14.0398	14.7883	14.3497	11.5958	11.5383	12.2345	11.8608
B3GALNT1	6.9046	7.1983	7.3588	5.4396	5.7534	5.1495	5.2271
ARL6IP1	9.3528	9.7533	10.2369	7.1008	6.8733	7.0401	6.47
HSP90AA1	13.77	14.2042	14.4562	11.9328	11.6748	12.0011	12.5483
SMARCE1	10.805	10.624	10.8504	8.6299	8.6116	9.0388	8.7935
TAB2	7.5081	6.6244	7.066	4.5429	4.1972	4.0864	3.2126
MRFAP1L1	8.6628	9.0161	8.3401	5.4882	5.249	5.1058	5.6341
KRT17	7.1281	9.1361	7.3964	5.0544	3.9103	2.9569	3.6594
TMEM97	10.7527	10.6704	10.8993	8.5704	7.4634	7.6404	7.032
TXLNA	9.8168	10.2153	10.3343	6.6063	6.2125	6.8855	7.0768
ELF1	8.9602	8.7776	8.683	6.8155	6.2014	5.8906	6.1677
ADO	7.2936	7.0851	7.1001	4.5122	4.2758	4.92	5.5304
CEBPB	15	15	15	12.908	13.0081	12.7249	13.5078
UBE2E1	8.7508	8.729	9.279	6.8918	5.7749	5.2687	5.7781
JMJD6	10.2462	10.7694	11.0104	8.0165	7.2306	7.5946	8.1932
TRIM37	12.6181	13.7061	12.6073	9.9229	10.4946	10.8547	9.5216
TSPYL5	7.9617	8.5887	10.6035	3.489	4.6476	4.4452	4.4075
ZBTB1	7.9655	7.7116	7.7647	6.2617	6.1513	6.3303	6.4053
RAB22A	9.6732	9.7115	9.6112	8.062	7.4418	7.2863	7.6026
MTMR4	9.4924	9.4679	8.8054	6.582	6.9555	7.4752	6.5455
HNRNPA1	12.0083	11.586	12.4981	9.3221	9.0468	9.7769	9.4944
WDR43	9.6744	9.9272	9.8239	8.5193	7.8147	7.7456	7.7724
SEC16A	9.1457	9.7905	8.9022	7.5259	7.0472	7.0572	7.3998
RBBP4	9.6256	9.5016	9.1855	7.4815	7.1602	7.0502	7.8127
UBE2Z	10.2398	10.5938	10.5826	8.1395	7.9507	8.077	7.8303
YTHDF2	8.8817	8.5042	8.4457	6.8607	5.8937	5.5385	6.2944
SYNCRIP	9.7452	10.0943	10.6565	7.2804	7.8664	7.1008	7.9567
CAB39	7.82	6.9324	7.5781	5.1465	5.6181	5.4294	5.6267
BAG3	12.5282	12.8969	12.7125	9.5022	8.937	9.4701	10.2389
RPS27L	10.13	10.8701	10.3801	8	7.9542	7.9596	7.7373
PRC1	9.1176	9.1242	9.9343	6.272	6.9117	6.1468	7.3808
NMD3	10.4195	10.0497	10.475	7.1959	7.4844	7.8046	7.4875
FTSJ3	10.7851	10.9749	10.5059	8.6322	8.9761	9.2006	9.1619

ZNF711 transcriptional regulatory sub-network

The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network

ARTICLE: ZNF711

[1] Clinical Significance of ZNF711 in Human Breast Cancer.

[2] Prediction of competing endogenous RNA coexpression network as prognostic markers in AML.

[3] A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation.

[4] Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders.

[5] Mutations in two large pedigrees highlight the role of ZNF711 in X-linked intellectual disability.

[6] A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation.

[7] Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters.

[8] Fine mapping of Xq11.1-q21.33 and mutation screening of RPS6KA6, ZNF711, ACSL4, DLG3, and IL1RAPL2 for autism spectrum disorders (ASD).

[9] Interactions of cullin3/KCTD5 complexes with both cytoplasmic and nuclear proteins: Evidence for a role in protein stabilization.

[10] ZFX acts as a transcriptional activator in multiple types of human tumors by binding downstream of transcription start sites at the majority of CpG island promoters.

Transcription factor KEGG

The KEGG pathway of the TF in this TRN is shown below