NETWORK ID: CN34638 |
AGO1 transcriptional regulatory sub-network
| EXPERIMENTS | |
| condition | PRCP |
| condition dose | |
| condition time | 144 h |
| CELL LINE | MCF7 |
| CONDITION DETALIS | ||
| ID | TRCN0000050808 | |
| name | PRCP | |
| type | trt_sh; shRNA | |
Differential expressed genes in this transcriptional regulatory sub-network
If you want to view heatmap, you can click [expand]
You can download all DEGs data.
| Symbol | control | control | control | condition | condition |
|---|---|---|---|---|---|
| ACADM | 6.9378 | 7.3194 | 7.0132 | 5.3771 | 5.7002 |
| ADH1B | 3.7886 | 3.7135 | 3.628 | 1.9694 | 1.1402 |
| ADH1C | 6.5568 | 6.9411 | 6.5815 | 5.4329 | 5.1599 |
| CCNA2 | 8.3747 | 9.2535 | 9.468 | 5.3456 | 6.3485 |
| CD58 | 10.0221 | 9.9715 | 9.8742 | 8.4263 | 8.2887 |
| CDK1 | 10.6323 | 10.8212 | 10.4043 | 7.6051 | 8.8038 |
| CDC25B | 11.6995 | 11.2467 | 12.1153 | 10.0699 | 9.7565 |
| CKS1B | 12.0362 | 12.4788 | 11.8258 | 9.8279 | 10.4149 |
| CKS2 | 11.5414 | 12.3264 | 12.0511 | 9.4605 | 9.7762 |
| CP | 6.7358 | 7.1987 | 6.3165 | 3.2833 | 4.3158 |
| CPOX | 7.9943 | 8.4632 | 8.0494 | 6.8982 | 6.74 |
| CTSD | 14.2673 | 14.1929 | 14.2267 | 13.0161 | 13.2309 |
| DCK | 9.9222 | 9.8293 | 9.8175 | 7.864 | 7.9206 |
| DPH2 | 7.4191 | 7.458 | 7.7416 | 5.7492 | 5.6902 |
| FEN1 | 10.5116 | 9.9805 | 10.4057 | 8.5819 | 9.1234 |
| FLT3 | 5.8668 | 5.6587 | 5.5584 | 4.5807 | 4.7218 |
| GABRP | 8.5362 | 8.5107 | 8.5886 | 7.6254 | 7.3506 |
| HMGB2 | 9.4444 | 9.9158 | 10.3568 | 6.7273 | 6.8189 |
| HOXC4 | 6.3448 | 5.9922 | 6.0365 | 4.4722 | 4.7501 |
| HOXC6 | 8.2959 | 7.9755 | 8.2299 | 3.1732 | 4.9424 |
| HOXC10 | 2.3457 | 2.8072 | 3.4766 | 0.5281 | 0.9058 |
| IGFBP1 | 5.8846 | 6.1801 | 6.2112 | 4.6096 | 4.4204 |
| ILK | 9.7673 | 9.5922 | 9.5673 | 8.6406 | 8.5 |
| IMPDH2 | 11.1285 | 10.5201 | 11.3057 | 8.9734 | 9.2696 |
| KIF11 | 7.2765 | 7.6269 | 7.2478 | 5.3382 | 6.1358 |
| LMNB1 | 10.1299 | 9.8526 | 10.2487 | 8.2425 | 8.5929 |
| LOX | 2.6753 | 2.5537 | 3.1147 | 1.418 | 1.0963 |
| MAD2L1 | 9.4361 | 10.3078 | 9.492 | 6.0219 | 7.0107 |
| MCM5 | 9.6028 | 9.0576 | 9.3726 | 6.858 | 7.5668 |
| MT1M | 4.8471 | 5.0434 | 5.3664 | 3.163 | 2.8851 |
| MYBL2 | 10.3019 | 10.0622 | 10.4113 | 7.7484 | 8.7936 |
| PCNA | 13.2095 | 13.5325 | 13.4622 | 10.59 | 11.6979 |
| PLIN1 | 4.8787 | 5.5226 | 5.6768 | 3.2018 | 3.1653 |
| FXYD1 | 7.2453 | 7.565 | 8.061 | 5.914 | 5.1323 |
| FXYD3 | 11.9549 | 12.2275 | 11.6502 | 10.5116 | 10.7491 |
| POLE2 | 8.0979 | 8.9829 | 8.4123 | 5.2317 | 6.5321 |
| PSMA5 | 12.3778 | 12.4767 | 11.8871 | 10.9582 | 10.9809 |
| PSMA6 | 11.5476 | 11.5849 | 11.8419 | 10.785 | 10.5585 |
| PTPN13 | 7.5701 | 7.7467 | 7.2332 | 5.9172 | 6.2772 |
| RAD1 | 8.6195 | 8.8224 | 8.685 | 7.6427 | 7.3526 |
| RFC3 | 9.9263 | 10.3528 | 9.7812 | 8.4508 | 8.5442 |
| RFC4 | 10.2375 | 10.2767 | 10.025 | 7.208 | 8.3959 |
| RPA3 | 9.7944 | 9.7907 | 9.7166 | 6.6228 | 7.3055 |
| RRM1 | 10.3308 | 10.4704 | 10.7227 | 8.5159 | 9.2011 |
| SAA4 | 4.7069 | 5.0686 | 4.8962 | 3.7624 | 3.7117 |
| SKP2 | 9.1061 | 9.1944 | 8.3724 | 6.7137 | 6.9778 |
| DEK | 9.3673 | 10 | 10.0799 | 8.0194 | 8.2771 |
| CDC7 | 8.403 | 8.0789 | 7.972 | 6.7337 | 6.8329 |
| SAP30 | 7.3491 | 8.2488 | 7.8988 | 5.9368 | 6.2164 |
| PRC1 | 7.7045 | 8.3297 | 8.2668 | 6.1865 | 6.4374 |
| CCNB2 | 10.1005 | 10.3614 | 10.5189 | 7.7179 | 8.9382 |
| AURKB | 8.8306 | 8.6541 | 8.6967 | 6.7203 | 6.9283 |
| ADIPOQ | 3.5504 | 3.725 | 3.9307 | 2.4674 | 2.1962 |
| SNRNP40 | 8.7802 | 8.7612 | 9.0164 | 7.9347 | 7.6958 |
| PRDX6 | 12.0023 | 11.6938 | 11.8202 | 10.1354 | 10.5314 |
| RNF14 | 6.5944 | 7.0434 | 6.7865 | 5.6637 | 5.8055 |
| ESPL1 | 8.6994 | 8.376 | 8.175 | 7.0001 | 7.1375 |
| NR1D2 | 3.6393 | 4.1754 | 3.6915 | 2.3949 | 2.4889 |
| TROAP | 8.1519 | 7.8003 | 7.9002 | 6.5533 | 6.9699 |
| NET1 | 9.9317 | 9.8696 | 10.2128 | 8.217 | 8.5962 |
| ABCA8 | 5.8794 | 5.9397 | 5.7151 | 4.8402 | 4.8779 |
| RNASEH2A | 10.4457 | 10.6191 | 10.4468 | 9.0243 | 9.0728 |
| ANP32B | 12.1754 | 12.0186 | 12.0328 | 10.5194 | 10.6626 |
| SLC19A2 | 10.1885 | 10.7002 | 10.3979 | 8.6396 | 8.5033 |
| RAD51AP1 | 8.7119 | 8.8778 | 8.4033 | 6.8061 | 7.3235 |
| DBF4 | 8.1467 | 8.5392 | 8.418 | 6.768 | 7.1575 |
| SLC27A2 | 6.4662 | 6.1334 | 6.7983 | 4.3563 | 4.9197 |
| CIT | 6.9881 | 6.6668 | 7.1678 | 5.5504 | 5.7845 |
| CHEK2 | 8.5212 | 8.9215 | 8.5737 | 6.4878 | 7.233 |
| CD300A | 4.4053 | 4.3383 | 4.3356 | 2.7473 | 3.1669 |
| EXOSC8 | 10.6442 | 10.5532 | 10.474 | 9.453 | 9.6537 |
| RPIA | 10.3295 | 9.8451 | 10.3773 | 7.9574 | 8.8471 |
| WDTC1 | 8.8227 | 8.8505 | 8.5581 | 7.6362 | 7.6296 |
| PPIP5K2 | 8.9728 | 8.8991 | 8.2878 | 6.8122 | 7.2976 |
| NCAPD3 | 7.6594 | 7.7508 | 7.3875 | 5.6133 | 6.459 |
| ITGB3BP | 8.7246 | 9.042 | 8.8232 | 7.0261 | 6.4476 |
| WWTR1 | 7.7513 | 7.8049 | 7.8144 | 6.8671 | 6.332 |
| TPGS2 | 9.216 | 9.4638 | 9.121 | 7.9769 | 7.7341 |
| LRIG1 | 7.4616 | 7.2561 | 7.2753 | 5.0083 | 5.3898 |
| PTTG3P | 5.6445 | 5.7357 | 5.4932 | 4.6314 | 4.696 |
| LSM3 | 11.2197 | 11.3426 | 11.5576 | 10.1714 | 10.0716 |
| MRPS28 | 12.0086 | 12.2354 | 12.0934 | 11.0035 | 10.9505 |
| RACGAP1 | 9.7433 | 9.8571 | 9.8585 | 8.3542 | 8.4299 |
| GPSM2 | 9.5673 | 9.5946 | 9.4993 | 8.615 | 8.7508 |
| FAM216A | 7.9679 | 8.1626 | 8.1954 | 7.1704 | 7.1508 |
| GPN3 | 8.1256 | 8.83 | 8.6295 | 6.9699 | 7.2336 |
| MRPL35 | 9.2561 | 9.3429 | 8.6116 | 7.6574 | 7.5181 |
| RNF138 | 7.8355 | 8.2447 | 7.9008 | 6.6163 | 7.0173 |
| DTL | 6.9432 | 7.3212 | 7.3229 | 4.4523 | 5.6655 |
| SPDL1 | 6.5177 | 6.8511 | 6.5336 | 5.3759 | 5.6664 |
| CDCA8 | 9.6865 | 9.6206 | 9.3124 | 7.5223 | 8.2668 |
| ASF1B | 10.2354 | 10.2062 | 10.0322 | 8.1028 | 8.7092 |
| COA1 | 8.9997 | 9.5387 | 9.2235 | 7.6082 | 8.0035 |
| DTWD1 | 8.0202 | 7.9311 | 8.0794 | 6.8309 | 6.6437 |
| KIF15 | 5.6149 | 5.5223 | 5.854 | 3.8598 | 4.5763 |
| TRMT5 | 12.6333 | 12.2632 | 11.931 | 10.6521 | 10.692 |
| LSM2 | 9.8924 | 9.7944 | 10.2699 | 8.2472 | 8.7773 |
| TGIF2 | 6.5771 | 6.8492 | 6.1042 | 5.0584 | 5.1737 |
| NIF3L1 | 8.9114 | 8.9655 | 8.6676 | 7.3189 | 7.8469 |
| DCLRE1B | 8.0134 | 8.0889 | 7.9206 | 7.1656 | 7.0568 |
| WDR61 | 10.5997 | 10.4781 | 10.26 | 8.729 | 9.348 |
| CDCA3 | 8.8815 | 8.9142 | 8.9997 | 7.4648 | 7.9147 |
| TUBB6 | 9.7806 | 9.8975 | 9.7652 | 7.5509 | 8.2584 |
AGO1 transcriptional regulatory sub-network
The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network
More information of [PRCP] and [AGO1]. Click to[expand]
Curated target protein/gene of this condition/drug
Protein target or gene target of this condition curated by previous studies and their associated KEGG pathways are shown below
| Target Gene | Protein | Amino acids | More |
|
PRCP |
Lysosomal Pro-X carboxypeptidase
|
496
|
ARTICLE: PRCP
[1] Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.
[2] Prolylcarboxypeptidase (PRCP) as a new target for obesity treatment.
[3] PRCP regulates angiogenesis in vivo.
[4] New aspects of melanocortin signaling: a role for PRCP in -MSH degradation.
TRANSCRIPTION FACTOR: AGO1
| Gene | Protein | Amino acids | More |
|
AGO1 |
Protein argonaute-1
|
857
|