NETWORK ID: CN34650 |
TCF12 transcriptional regulatory sub-network
| EXPERIMENTS | |
| condition | BNIP3 |
| condition dose | |
| condition time | 96 h |
| CELL LINE | MCF7 |
| CONDITION DETALIS | ||
| ID | TRCN0000007833 | |
| name | BNIP3 | |
| type | trt_sh; shRNA | |
Differential expressed genes in this transcriptional regulatory sub-network
If you want to view heatmap, you can click [expand]
You can download all DEGs data.
| Symbol | control | control | control | condition | condition |
|---|---|---|---|---|---|
| ALDH3A1 | 5.9601 | 6.1201 | 6.3343 | 4.6775 | 5.1185 |
| ALDH1A3 | 8.1598 | 6.9559 | 6.8315 | 5.7095 | 4.7059 |
| APOE | 5.8614 | 6.5771 | 7.1244 | 5.1769 | 5.0373 |
| RHOB | 10.2087 | 10.0538 | 8.7584 | 7.3947 | 8.4376 |
| ATF1 | 9.103 | 8.3543 | 8.7608 | 7.4115 | 7.2094 |
| ATP2A3 | 7.6381 | 7.4731 | 8.2528 | 6.6391 | 6.795 |
| BAG1 | 7.9729 | 7.8723 | 8.2471 | 6.7971 | 7.2836 |
| CCND1 | 8.0892 | 8.7099 | 8.874 | 6.6698 | 6.7659 |
| RUNX1 | 6.4133 | 6.7916 | 6.659 | 5.0862 | 5.1688 |
| CBR3 | 5.825 | 5.7076 | 7.2389 | 4.7603 | 4.3008 |
| CDC6 | 6.8085 | 6.757 | 7.364 | 5.7572 | 5.7984 |
| CDH1 | 9.3445 | 8.2748 | 9.1392 | 5.5708 | 7.7485 |
| CDH3 | 8.1509 | 7.3176 | 7.8232 | 5.7233 | 6.5129 |
| ABCC2 | 6.7846 | 6.1257 | 7.0165 | 5.3878 | 5.2934 |
| CNN2 | 7.3025 | 7.6724 | 7.8889 | 6.6803 | 6.3597 |
| COL5A1 | 5.3323 | 5.1086 | 5.1121 | 4.6278 | 3.8919 |
| COMP | 3.588 | 4.1994 | 3.8871 | 3.1477 | 2.811 |
| CRABP2 | 12.0501 | 13.0765 | 13.4562 | 10.7923 | 11.2356 |
| NQO1 | 14.0465 | 13.8655 | 14.7166 | 10.9302 | 10.7651 |
| DSP | 7.7401 | 7.1554 | 9.2845 | 5.7901 | 5.7331 |
| EGR2 | 5.492 | 5.4436 | 6.1684 | 4.5175 | 4.5859 |
| EGR3 | 7.2906 | 7.1668 | 6.4717 | 4.6539 | 6.0961 |
| EIF4EBP1 | 9.6494 | 10.2639 | 9.5701 | 8.5057 | 8.3612 |
| FDFT1 | 12.5795 | 12.5763 | 12.3956 | 11.7938 | 11.7563 |
| FDX1 | 10.6203 | 9.781 | 10.6022 | 9.1198 | 8.3631 |
| FKBP5 | 6.9234 | 6.6784 | 6.546 | 5.6431 | 5.2292 |
| FOXG1 | 5.3942 | 4.7503 | 5.5152 | 4.1832 | 4.309 |
| FOLR1 | 4.7463 | 5.8305 | 5.0763 | 2.817 | 4.1235 |
| GPX2 | 7.6319 | 7.0908 | 6.7713 | 5.842 | 5.6312 |
| ITPR3 | 6.9754 | 7.4336 | 7.0123 | 5.0101 | 5.8359 |
| JUP | 12.0631 | 10.0846 | 11.3125 | 8.9849 | 9.3566 |
| KRAS | 8.7203 | 7.809 | 8.0158 | 6.6013 | 6.6465 |
| KRT17 | 7.3445 | 7.1664 | 7.874 | 6.1913 | 5.965 |
| KRT18 | 13.9567 | 13.9238 | 12.0429 | 11.4872 | 9.7262 |
| KRT19 | 11.7829 | 12.8316 | 12.3004 | 10.4989 | 11.2755 |
| EPCAM | 7.6396 | 6.94 | 7.7515 | 4.7769 | 5.5767 |
| RAB8A | 11.2192 | 10.7651 | 11.345 | 10.164 | 9.8652 |
| MFAP2 | 7.0916 | 8.2223 | 8.1133 | 6.6115 | 6.4801 |
| MICB | 6.6361 | 6.6358 | 7.2828 | 5.566 | 5.2183 |
| ABCC1 | 7.1672 | 7.2721 | 7.3672 | 5.3728 | 6.6195 |
| MUC5AC | 6.174 | 6.735 | 6.8978 | 4.8818 | 5.6289 |
| MYBL1 | 9.2733 | 8.1273 | 10.5425 | 7.5168 | 6.7895 |
| NEK2 | 7.8413 | 8.058 | 7.3412 | 6.7435 | 6.749 |
| NOTCH1 | 8.9138 | 8.238 | 9.0224 | 6.1897 | 7.0363 |
| SERPINA5 | 5.8906 | 8.0998 | 7.4823 | 5.0947 | 5.2442 |
| FXYD3 | 11.7411 | 10.3702 | 12.3906 | 8.3962 | 8.1033 |
| PPP1CA | 11.8666 | 11.7888 | 11.2376 | 10.8417 | 10.5947 |
| RAP1GAP | 9.8621 | 10.4324 | 9.5599 | 6.7498 | 7.9862 |
| S100A2 | 4.5067 | 4.7234 | 4.3611 | 3.4534 | 3.4982 |
| S100P | 9.994 | 9.4151 | 12.2724 | 6.5385 | 7.1749 |
| SCNN1A | 3.2839 | 3.0755 | 2.8553 | 0.3362 | 1.2667 |
| SDC1 | 12.6921 | 11.7829 | 12.9196 | 8.1445 | 10.8598 |
| CXCL12 | 9.0462 | 8.7833 | 9.8868 | 6.8224 | 8.1835 |
| SGK1 | 7.588 | 8.1733 | 8.8568 | 6.7933 | 6.7867 |
| SMTN | 8.272 | 7.9038 | 8.0718 | 7.1946 | 7.2401 |
| SNAI2 | 8.1235 | 7.6763 | 8.1187 | 5.5697 | 6.1244 |
| ST14 | 7.2529 | 6.7468 | 7.6645 | 5.792 | 5.6954 |
| KLF10 | 6.3335 | 5.1652 | 5.3617 | 4.4465 | 3.0943 |
| TK1 | 10.496 | 10.4789 | 10.709 | 9.3861 | 9.7018 |
| TNNT1 | 12.8716 | 11.9871 | 13.3343 | 10.7485 | 9.4415 |
| TPD52L1 | 10.2205 | 10.5746 | 10.2869 | 8.1591 | 6.981 |
| TRAF5 | 7.9446 | 7.9735 | 7.985 | 7.1552 | 6.6023 |
| PHLDA2 | 10.7732 | 11.8907 | 10.6633 | 8.2109 | 9.7723 |
| UCP2 | 12.8202 | 12.0749 | 11.54 | 9.6969 | 10.4568 |
| UGDH | 11.47 | 11.2507 | 11.1128 | 10.3264 | 9.3809 |
| COL14A1 | 6.5504 | 6.0444 | 6.7472 | 5.4372 | 5.4673 |
| XBP1 | 13.0137 | 12.7379 | 12.4757 | 10.2679 | 11.6133 |
| PSCA | 6.2538 | 7.4723 | 7.436 | 5.255 | 5.838 |
| CDC45 | 8.9019 | 8.7593 | 9.4046 | 6.0964 | 7.535 |
| TAGLN2 | 8.8056 | 8.9382 | 8.8674 | 7.2966 | 7.9642 |
| ANXA9 | 7.5763 | 7.5678 | 7.9456 | 6.2968 | 7.036 |
| RGS20 | 5.7252 | 4.7298 | 5.3905 | 3.6907 | 4.2709 |
| IER3 | 9.7616 | 10.9262 | 9.3801 | 6.628 | 8.0318 |
| SELENBP1 | 8.566 | 9.1951 | 8.8901 | 6.9706 | 8.1607 |
| PAPSS2 | 13.2401 | 13.315 | 12.4019 | 11.6957 | 11.6372 |
| SLC16A6 | 7.6101 | 7.6797 | 7.5752 | 6.5019 | 7.0593 |
| SLC16A5 | 6.8066 | 6.3982 | 6.4061 | 5.2367 | 5.7839 |
| EXO1 | 7.4197 | 7.2856 | 7.1915 | 6.0619 | 6.6569 |
| AURKB | 7.9896 | 9.2621 | 8.2484 | 7.344 | 7.062 |
| TRIP13 | 9.8178 | 10.1601 | 9.6969 | 8.7789 | 9.0757 |
| SLC9A3R1 | 11.2581 | 10.7529 | 11.3863 | 9.5085 | 9.1658 |
| SH3BP5 | 9.6516 | 9.5735 | 9.6145 | 8.2995 | 8.6948 |
| AKAP12 | 4.4012 | 4.3598 | 4.3146 | 2.9698 | 3.458 |
| NCOR2 | 8.8814 | 9.3804 | 8.4723 | 7.4809 | 7.8629 |
| TRAF4 | 8.0123 | 7.9134 | 8.5353 | 6.5415 | 6.9948 |
| ARPC1B | 13.0199 | 12.227 | 12.6493 | 11.3037 | 11.2647 |
| PPIF | 10.7235 | 10.1741 | 10.2555 | 9.4364 | 9.1922 |
| AGR2 | 11.1084 | 10.2467 | 12.9461 | 9.31 | 7.0403 |
| ST6GALNAC2 | 8.3985 | 8.4424 | 9.9769 | 6.2864 | 7.0434 |
| TRIM16 | 10.2217 | 10.019 | 9.7708 | 9.3136 | 9.0834 |
| KLK11 | 5.4591 | 5.1875 | 5.3156 | 3.7649 | 4.6345 |
| RBPMS | 10.1766 | 9.7594 | 8.8035 | 8.4329 | 8.009 |
| RAB31 | 10.2989 | 9.7868 | 9.3249 | 8.6823 | 8.4725 |
| PRSS23 | 12.1776 | 12.2832 | 11.8021 | 9.8018 | 10.2217 |
| GALNT6 | 10.9125 | 10.3792 | 11.6531 | 8.9564 | 9.1066 |
| JADE2 | 6.9215 | 6.7769 | 6.4375 | 5.9065 | 5.6387 |
| LRRC8B | 5.8652 | 5.9772 | 6.3096 | 4.9703 | 5.4174 |
| TSKU | 10.5668 | 9.7481 | 9.4525 | 6.9079 | 6.4447 |
| PHGDH | 11.1492 | 11.54 | 9.5935 | 8.3551 | 8.5965 |
| HSPB8 | 13.1296 | 14.1484 | 11.9282 | 10.3328 | 11.4314 |
| MYOF | 9.8354 | 9.2488 | 9.7304 | 8.1554 | 7.3785 |
| TMEM14A | 9.5672 | 9.2323 | 9.5772 | 8.7629 | 8.2084 |
| FHOD1 | 8.4852 | 8.3752 | 8.5743 | 7.6319 | 7.6461 |
| PACSIN3 | 7.4796 | 7.5625 | 8.6237 | 6.4641 | 6.585 |
| GAL | 8.6151 | 8.6708 | 8.0131 | 6.7707 | 7.5759 |
| CHST15 | 7.7157 | 5.9919 | 6.6965 | 5.4194 | 4.0804 |
| GINS2 | 10.5683 | 10.4863 | 10.3934 | 8.1013 | 9.551 |
| ESRP1 | 7.6825 | 7.4499 | 8.0049 | 6.8108 | 6.9582 |
| RASIP1 | 5.794 | 5.7217 | 6.4653 | 5.053 | 4.4902 |
| MOCOS | 7.2226 | 7.247 | 6.7669 | 5.5833 | 5.1173 |
| CEP55 | 7.724 | 6.9434 | 6.8859 | 6.334 | 5.3799 |
| CWF19L1 | 7.1313 | 6.8187 | 7.0053 | 6.3617 | 5.9828 |
| AKR1B10 | 8.0388 | 6.8078 | 9.1245 | 5.9863 | 5.0871 |
| S100A14 | 9.9568 | 10.0341 | 11.5643 | 8.6045 | 8.868 |
| PERP | 8.6486 | 7.9281 | 9.6841 | 7.3558 | 6.6252 |
| NXN | 8.0093 | 7.4892 | 8.8889 | 5.8176 | 6.2812 |
| VTCN1 | 4.2414 | 4.3755 | 3.9403 | 3.3157 | 3.3478 |
| DENND2D | 9.0034 | 8.7364 | 9.2593 | 7.4797 | 6.6368 |
| WDR76 | 6.0708 | 5.6203 | 6.366 | 5.1912 | 4.9498 |
| SPSB1 | 7.0612 | 7.2271 | 7.3305 | 5.985 | 6.5296 |
| MUC5B | 5.8329 | 6.7993 | 7.2245 | 4.7585 | 5.4818 |
TCF12 transcriptional regulatory sub-network
The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network
More information of [BNIP3] and [TCF12]. Click to[expand]
Curated target protein/gene of this condition/drug
Protein target or gene target of this condition curated by previous studies and their associated KEGG pathways are shown below
| Target Gene | Protein | Amino acids | More |
|
BNIP3 |
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
|
194
|
ARTICLE: BNIP3
[4] Role of BNIP3 and NIX in cell death, autophagy, and mitophagy.
[5] BNIP3 promotes HIF-1 -driven melanoma growth by curbing intracellular iron homeostasis.
[6] Bnip3 mediates doxorubicin-induced cardiomyocyte pyroptosis via caspase-3/GSDME.
[7] BNIP3 and Nix: Atypical regulators of cell fate.
[8] Activation of BNIP3-mediated mitophagy protects against renal ischemia-reperfusion injury.
TRANSCRIPTION FACTOR: TCF12
| Gene | Protein | Amino acids | More |
|
TCF12 |
Transcription factor 12
|
682
|
ARTICLE: TCF12
[2] Tcf12 balances the reconstitution and differentiation capacity of hematopoietic stem cell.
[3] Tcf12 and NeuroD1 cooperatively drive neuronal migration during cortical development.
[5] Embryonic requirements for Tcf12 in the development of the mouse coronal suture.
[7] Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders.
[8] Clinical genetics of craniosynostosis.
[9] TCF12 Deficiency Impairs the Proliferation of Glioblastoma Tumor Cells and Improves Survival.
[10] TCF12 overexpression as a poor prognostic factor in ovarian cancer.