NETWORK ID: CN35931 |
YAP1 transcriptional regulatory sub-network
| EXPERIMENTS | |
| condition | GSK3A |
| condition dose | |
| condition time | 96 h |
| CELL LINE | MCF7 |
| CONDITION DETALIS | ||
| ID | TRCN0000038679 | |
| name | GSK3A | |
| type | trt_sh; shRNA | |
Differential expressed genes in this transcriptional regulatory sub-network
If you want to view heatmap, you can click [expand]
You can download all DEGs data.
| Symbol | control | control | control | condition | condition |
|---|---|---|---|---|---|
| AOC1 | 5.7725 | 5.8349 | 5.1671 | 7.4943 | 8.6448 |
| ADORA2B | 6.8328 | 6.8674 | 7.0436 | 7.6648 | 8.0232 |
| JAG1 | 8.0989 | 8.0222 | 8.654 | 11.5947 | 10.5755 |
| ATP6V0A1 | 7.1636 | 7.3086 | 7.668 | 8.3592 | 8.6028 |
| BCL2L1 | 8.1824 | 8.8123 | 8.1556 | 9.7271 | 9.3039 |
| BLVRB | 10.8924 | 11.445 | 11.2075 | 13.2493 | 12.9014 |
| BMP7 | 8.7664 | 9.4569 | 8.7705 | 10.8714 | 9.9313 |
| BMPR2 | 5.3833 | 5.5616 | 5.9704 | 6.5922 | 6.7234 |
| RUNX1T1 | 5.1087 | 5.0579 | 5.9505 | 7.029 | 6.7203 |
| CEACAM5 | 6.3111 | 5.118 | 6.8327 | 10.9702 | 8.4233 |
| CEACAM7 | 5.3317 | 6.4093 | 4.806 | 7.8233 | 7.0293 |
| CLTB | 12.1718 | 12.4424 | 11.591 | 13.5248 | 13.5103 |
| COL5A2 | 4.8759 | 4.4184 | 5.3674 | 6.6631 | 7.0821 |
| COMP | 3.9085 | 3.3372 | 4.1591 | 5.3614 | 5.3485 |
| CYP27B1 | 6.5089 | 6.7309 | 6.434 | 7.5972 | 7.4323 |
| DHCR24 | 9.9718 | 10.5887 | 9.7581 | 12.1573 | 11.4978 |
| HBEGF | 6.232 | 6.6582 | 6.7099 | 7.6508 | 8.3462 |
| EPHA2 | 8.4448 | 8.2871 | 8.3217 | 9.3707 | 9.1801 |
| FMOD | 7.0902 | 6.825 | 7.4428 | 8.1772 | 8.0271 |
| FUT8 | 9.8021 | 8.9683 | 9.5119 | 10.5425 | 10.6957 |
| GLRX | 5.1163 | 4.8048 | 6.0115 | 7.861 | 7.8313 |
| SFN | 10.3998 | 10.3187 | 9.1415 | 11.2819 | 12.3007 |
| GSK3B | 9.3607 | 8.9416 | 9.0688 | 10.2454 | 10.4516 |
| HAS1 | 4.4376 | 4.3429 | 4.786 | 5.3341 | 6.4057 |
| HK2 | 6.4504 | 7.2909 | 7.053 | 8.8412 | 8.7113 |
| ID3 | 8.7111 | 8.9985 | 9.0344 | 9.7362 | 9.702 |
| ITGAM | 6.0998 | 6.008 | 5.9972 | 6.7441 | 6.9793 |
| ITGB2 | 3.5427 | 3.2529 | 3.6718 | 4.3062 | 4.6785 |
| KRT19 | 12.2453 | 13.4937 | 13.1716 | 14.4303 | 15 |
| LAD1 | 8.0615 | 7.7713 | 7.9145 | 9.2995 | 9.0614 |
| LAMC2 | 5.8083 | 5.1659 | 4.6798 | 6.6656 | 6.4598 |
| LMNA | 8.5514 | 9.1478 | 8.5689 | 9.8005 | 9.8385 |
| EPCAM | 6.9015 | 5.359 | 6.0923 | 8.3586 | 9.4236 |
| MGST3 | 9.7867 | 9.2326 | 8.9372 | 11.0957 | 10.9828 |
| MMP19 | 4.3244 | 4.4791 | 4.2103 | 5.3468 | 5.6934 |
| CEACAM6 | 3.1387 | 1.3419 | 3.9705 | 9.5744 | 7.8901 |
| PLAUR | 3.7342 | 3.7575 | 3.4903 | 4.5212 | 5.6034 |
| PLOD2 | 6.8678 | 5.9101 | 5.8729 | 8.5932 | 8.1967 |
| PLXNA1 | 9.8948 | 9.2995 | 10.2634 | 11.3584 | 11.5282 |
| PPIC | 10.2582 | 9.8395 | 8.9663 | 11.9276 | 11.6854 |
| DNAJC3 | 5.2235 | 5.0512 | 5.3256 | 6.0042 | 6.3066 |
| PRSS3 | 7.1659 | 6.5575 | 6.0159 | 7.937 | 8.0397 |
| PRTN3 | 2.9163 | 3.5102 | 3.8458 | 5.1838 | 4.9491 |
| PSMB2 | 10.8874 | 10.4757 | 10.981 | 11.6854 | 11.8796 |
| PSMD11 | 8.6885 | 8.8908 | 8.8844 | 10.416 | 9.6627 |
| PTPN12 | 7.5089 | 7.7651 | 8.0579 | 8.5793 | 9.4815 |
| RRAS | 8.1058 | 8.1787 | 7.4875 | 9.1145 | 8.9677 |
| S100A7 | 3.4472 | 3.3763 | 3.261 | 5.3187 | 6.3851 |
| S100A8 | 6.0591 | 5.9422 | 6.9031 | 8.4111 | 9.2714 |
| S100A11 | 12.6108 | 12.831 | 12.1417 | 15 | 14.4925 |
| S100P | 9.7687 | 7.8464 | 9.6707 | 15 | 11.8252 |
| SAT1 | 6.6017 | 6.498 | 6.1598 | 7.5696 | 7.6976 |
| SCD | 11.3804 | 11.5457 | 10.9431 | 12.6671 | 12.4744 |
| SDC2 | 4.0718 | 5.2627 | 3.3608 | 6.2866 | 6.1222 |
| SLC2A1 | 5.5835 | 6.1244 | 5.7328 | 7.6654 | 8.0474 |
| STX1A | 6.7587 | 6.8291 | 7.3785 | 10.8842 | 10.2097 |
| TEAD4 | 8.2238 | 8.2013 | 8.1836 | 9.1762 | 8.9542 |
| TFF2 | 5.2943 | 4.8149 | 4.9242 | 6.5709 | 6.0484 |
| TFF3 | 8.378 | 6.9145 | 8.8427 | 11.3437 | 10.5706 |
| TIMP2 | 8.2548 | 8.663 | 8.7191 | 10.2231 | 9.3752 |
| TIMP4 | 4.856 | 5.3549 | 5.3752 | 6.6857 | 6.4882 |
| TSPAN6 | 7.9479 | 7.6226 | 7.5046 | 8.7541 | 8.8174 |
| TMPRSS2 | 4.5537 | 4.93 | 4.0384 | 5.5743 | 5.8792 |
| TUBB2A | 6.6058 | 6.8386 | 7.2133 | 10.2979 | 8.2289 |
| UGDH | 10.1003 | 9.6471 | 10.288 | 11.9096 | 11.8116 |
| UPP1 | 8.8823 | 9.7691 | 9.4815 | 11.006 | 11.1093 |
| VIL1 | 3.6774 | 2.9578 | 2.9201 | 4.6786 | 4.5827 |
| CDC42BPA | 7.6931 | 7.3624 | 6.9894 | 8.3274 | 8.4927 |
| B4GALT4 | 5.8253 | 6.1045 | 6.546 | 7.7701 | 7.386 |
| ABCC3 | 9.8938 | 9.6947 | 9.5932 | 10.7948 | 11.1399 |
| IQGAP1 | 6.3409 | 7.0785 | 7.329 | 8.3575 | 8.4743 |
| ASAP2 | 8.3038 | 7.9675 | 7.6027 | 9.4235 | 9.3457 |
| WASL | 8.7137 | 8.759 | 9.0723 | 9.5731 | 10.3966 |
| GCNT3 | 5.7503 | 5.9248 | 6.0901 | 8.5641 | 7.5056 |
| KLF4 | 5.297 | 6.2396 | 5.5294 | 8.1046 | 7.1215 |
| NCOR2 | 8.8266 | 9.1175 | 9.4534 | 10.1856 | 10.0407 |
| MICAL2 | 4.4109 | 4.432 | 3.0548 | 6.2713 | 6.4934 |
| SCRN1 | 7.6883 | 7.7573 | 7.2174 | 8.5527 | 8.9229 |
| SH2D3A | 6.0626 | 6.0606 | 5.9556 | 6.7645 | 7.0491 |
| TSPAN5 | 4.0419 | 4.6444 | 4.8239 | 5.7588 | 5.4558 |
| TSPAN1 | 6.9134 | 6.0591 | 5.9825 | 9.4604 | 8.0754 |
| YAP1 | 6.2042 | 5.5037 | 5.631 | 7.8065 | 7.4916 |
| CAP1 | 10.5828 | 10.1708 | 10.6065 | 11.2713 | 12.2251 |
| SEMA3C | 9.4667 | 9.0511 | 9.2107 | 11.2612 | 11.7542 |
| FERMT2 | 9.0782 | 8.7316 | 8.584 | 10.1133 | 10.0084 |
| PKP3 | 7.8332 | 8.3528 | 8.4437 | 9.1597 | 9.5478 |
| ZNF365 | 4.6765 | 5.2108 | 5.2011 | 6.1293 | 6.2802 |
| TTC39A | 7.49 | 8.3146 | 8.4323 | 9.3189 | 9.4713 |
| LIMCH1 | 7.2282 | 7.4742 | 7.9135 | 9.4907 | 8.6933 |
| NMNAT2 | 4.5871 | 4.7872 | 3.7627 | 6.4187 | 5.6814 |
| SLC39A14 | 5.1064 | 5.5937 | 6.4998 | 8.6193 | 7.8997 |
| TIPARP | 7.2694 | 7.2656 | 6.9032 | 8.1261 | 8.039 |
| TES | 10.5406 | 10.4877 | 10.2961 | 11.5262 | 11.1837 |
| PLEK2 | 8.5345 | 8.017 | 8.5628 | 9.471 | 9.9454 |
| SRPX2 | 6.2604 | 6.5601 | 7.4612 | 8.2837 | 9.2594 |
| GOLIM4 | 5.1361 | 4.2251 | 4.4925 | 5.8272 | 6.5208 |
| CARD10 | 9.5595 | 8.9693 | 8.4493 | 10.9613 | 10.3828 |
| MINK1 | 8.2048 | 8.5871 | 8.6451 | 9.4121 | 10.5887 |
| DACT1 | 2.1297 | 2.4975 | 3.1933 | 5.6435 | 5.2879 |
| YIPF1 | 8.1061 | 8.3028 | 8.2217 | 8.9783 | 9.0455 |
| RHOF | 6.5445 | 7.7842 | 7.1115 | 8.6097 | 9.1103 |
| EPB41L4B | 8.0755 | 8.7084 | 8.1457 | 10.5406 | 10.0573 |
| PPP1R14D | 6.1188 | 5.8379 | 6.0562 | 6.8047 | 7.0912 |
| RETSAT | 5.8186 | 6.1543 | 6.9092 | 7.5815 | 7.8759 |
| FKBP14 | 4.488 | 4.9218 | 4.8219 | 6.3997 | 6.101 |
| WIPI1 | 7.2428 | 6.4803 | 7.2857 | 8.8923 | 8.5096 |
| TMEM45A | 4.4539 | 5.3671 | 5.9276 | 7.7424 | 7.3351 |
| TENM3 | 5.6859 | 5.8462 | 6.4414 | 7.2541 | 7.1739 |
| WSB2 | 10.1102 | 10.2739 | 10.718 | 12.9472 | 12.2109 |
| GNG12 | 8.2882 | 8.0987 | 9.0103 | 10.5934 | 10.327 |
| MUC13 | 6.0108 | 5.6886 | 5.391 | 7.7728 | 6.9856 |
| RAB25 | 5.429 | 6.2509 | 6.4366 | 8.0369 | 9.0519 |
| S100A14 | 9.986 | 10.3603 | 10.1285 | 12.3979 | 12.2168 |
| CIDEC | 5.0187 | 4.9411 | 5.2941 | 6.1126 | 5.9452 |
| TMBIM1 | 5.1596 | 5.7273 | 5.622 | 6.9749 | 6.465 |
| KLC2 | 7.7842 | 7.4346 | 7.5841 | 8.6736 | 8.3415 |
| PRR15L | 6.4762 | 6.2713 | 6.086 | 8.5407 | 7.4217 |
| EPS8L3 | 6.4848 | 5.9782 | 5.615 | 8.2882 | 7.2206 |
| GALNT12 | 3.5721 | 4.7789 | 4.4287 | 5.6906 | 5.9648 |
| LIN28A | 3.1092 | 3.219 | 3.5889 | 5.396 | 4.5613 |
| DNAJC22 | 7.3895 | 6.6507 | 7.4182 | 8.5088 | 8.5837 |
| MYO15B | 6.6538 | 6.1873 | 6.5846 | 7.4738 | 7.4486 |
| SLC44A4 | 4.9801 | 4.5509 | 3.5776 | 5.78 | 6.1664 |
| VOPP1 | 7.3023 | 6.6472 | 7.0794 | 7.862 | 8.2418 |
| EPPK1 | 4.9316 | 5.4187 | 5.1732 | 6.2613 | 6.1157 |
| MIR22HG | 5.5726 | 5.8094 | 5.3893 | 6.9479 | 6.6226 |
| AGAP1 | 7.2048 | 7.0923 | 6.9808 | 9.3244 | 8.5289 |
| MISP | 10.4298 | 9.6544 | 9.413 | 11.8796 | 10.931 |
| VSTM4 | 5.3769 | 5.3302 | 5.6761 | 6.2647 | 6.3986 |
| LPCAT4 | 7.0771 | 7.4043 | 7.6546 | 8.8436 | 8.4247 |
YAP1 transcriptional regulatory sub-network
The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network
More information of [GSK3A] and [YAP1]. Click to[expand]
Curated target protein/gene of this condition/drug
Protein target or gene target of this condition curated by previous studies and their associated KEGG pathways are shown below
| Target Gene | Protein | Amino acids | More |
|
GSK3A |
Glycogen synthase kinase-3 alpha
|
483
|
ARTICLE: GSK3A
[1] Epigenetic regulation in human melanoma: past and future.
[3] Isoform-specific GSK3A activity is negatively correlated with human sperm motility.
TRANSCRIPTION FACTOR: YAP1
| Gene | Protein | Amino acids | More |
|
YAP1 |
Transcriptional coactivator YAP1
|
504
|
ARTICLE: YAP1
[2] YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance.
[3] YAP1 protects against septic liver injury via ferroptosis resistance.
[6] YAP1 and PRDM14 converge to promote cell survival and tumorigenesis.
[7] Targeting YAP1/LINC00152/FSCN1 Signaling Axis Prevents the Progression of Colorectal Cancer.
[9] Role of YAP1 Signaling in Biliary Development, Repair, and Disease.