NETWORK ID: CN48945 | 

STAG2 transcriptional regulatory sub-network

EXPERIMENTS
condition PD-0325901
condition dose 0.12 uM
condition time 24 h
CELL LINE MCF10A
CONDITION DETALIS
ID BRD-K49865102
name PD-0325901
type trt_cp; compound
molecular formula C16H14F3IN2O4
molecular weight 482.19 g/mol
smiles
C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOCC(CO)O
clinical phase
Phase 2

Differential expressed genes in this transcriptional regulatory sub-network

If you want to view heatmap, you can click [expand]

You can download all DEGs data.

Symbolcontrolcontrolcontrolconditionconditioncondition
ADCY97.02476.72957.25798.65279.24288.8515
CFB6.939.04086.78410.478511.487810.7239
CDH16.49657.20277.01539.82749.10998.939
CDH39.54239.4619.622610.671811.123811.2404
CDKN1A10.852810.827410.747411.906812.089411.7028
CHRNA33.7864.13784.18745.53215.67915.8598
CLDN79.739710.1810.143312.113411.789111.8335
CUX15.10134.79615.08616.89696.77796.2517
DHCR2410.617410.680710.073811.750411.843111.6512
EPHX18.72658.41028.726811.664610.509110.9901
FABP36.49526.95366.51858.59248.73418.4108
FCER1G3.90473.77183.68835.22884.80244.6595
FOXO37.73647.13917.62418.60328.65768.5997
GALNT28.57727.75987.883710.20849.77479.527
GLUL5.41156.61725.44829.62418.08718.385
SFN10.72579.632310.468312.261612.239611.8564
GSTM32.1242.28361.13063.92673.76984.3225
HLA-F10.104210.480610.38111.967811.279111.7449
HLA-G8.52338.75878.78129.51659.72369.5838
HSPB110.562610.436410.238413.999814.063314.3089
IGF2R9.20749.32449.276610.7310.654410.7004
IL6R4.20734.64234.32255.60175.31765.3905
IRF68.82579.14299.117510.664510.562411.3939
JUP10.845310.361610.590812.973411.791112.7912
KRT134.89464.60245.2977.17856.43177.5751
KRT165.84214.82286.00878.53677.37777.5733
KRT179.12648.31239.484713.300111.371212.1715
TACSTD211.86712.122711.45313.737814.214913.2854
MAF7.27727.0837.23538.19588.38728.9721
MUC16.78146.58566.18378.185410.137210.111
MYCL4.0024.15484.425.76895.10025.8147
PIK3C2B6.04296.24336.64388.69598.73128.3565
POR5.14864.96365.30486.99156.48376.3288
PPL9.30189.11739.459612.429211.974412.4497
RGS210.00989.97699.905713.586612.524612.1612
S100A911.637411.625311.491913.615314.920814.0106
SPINT16.71347.12047.78349.411310.17319.9261
SRP1411.277711.466511.474312.587712.154212.6317
SULT1A27.46757.24887.38848.53968.52078.6078
STX49.4729.48479.23111.865910.983211.2525
SULT1A17.43917.28747.36579.05359.18699.1073
TAP18.02858.43498.33799.57719.17719.7742
THBS37.61548.36717.35499.75289.47699.082
TPM18.36648.57588.79810.200510.926910.3468
TUFT17.16457.69497.33839.59238.66739.4352
UBE2H6.6996.136.9667.72548.4668.4714
CREG112.754712.582712.888814.535113.814614.0668
TAX1BP19.30929.17379.207210.299610.27710.1091
MPZL110.439410.566410.322211.47311.775111.8583
STX810.01659.28279.847210.821211.018511.0122
LITAF10.903411.199810.259813.005412.420912.402
NPEPPS9.78049.99939.814810.922611.04311.2791
ISG154.87584.86944.83196.50697.24167.4766
PTPRU6.97387.46857.37738.74999.20028.6432
PDZK1IP14.81754.93165.17968.56689.67728.0731
VAT18.1217.44618.35549.874510.00939.8565
SMPDL3A8.31448.53828.39749.714410.401610.4578
DUSP107.19876.68556.51468.25668.37737.9869
OPN39.40169.01959.131811.445611.528911.3052
MXRA52.9893.56542.10934.78636.0415.9883
FBXO25.96026.04435.77687.60857.57596.869
SLCO3A17.03167.84787.04689.45269.23579.4124
PYCARD9.2379.12848.886212.453811.955812.1809
FAM8A17.29167.25697.55078.40738.82048.8096
CYB5R18.26538.05038.707710.40359.657310.5286
SYT178.49218.35227.80699.70589.7819.9166
WNT44.30854.38594.32655.34795.3585.197
HCFC1R19.32410.188310.035811.908811.260811.7298
SUSD45.45065.61875.57747.00556.55486.4042
BSDC19.51399.1799.409310.497210.520910.4921
LMBRD17.4227.20157.33748.15088.82818.5206
PAK65.70825.17115.55026.65936.6046.5586
RAB256.28435.54385.85017.70427.97267.5765
S100A1410.827110.521311.681613.237613.095613.6627
WFDC14.495.72025.36137.20187.08627.0776
PERP9.23428.918810.088511.617811.026312.176
MMP286.97837.3027.07758.48497.97388.1549
PGBD55.98315.78646.0387.10827.58767.1319
ZC3H12A7.19757.55257.08848.87158.62098.3057
AHNAK29.49869.594210.305512.178814.920812.9361

STAG2 transcriptional regulatory sub-network

The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network

More information of [PD-0325901] and [STAG2]. Click to[expand]

Curated target protein/gene of this condition/drug

Protein target or gene target of this condition curated by previous studies and their associated KEGG pathways are shown below

Target Gene Protein Amino acids More

MAP2K1
Dual specificity mitogen-activated protein kinase kinase 1
393
Uniport KEGGpathway

ARTICLE: PD-0325901

[1] MEK inhibitor PD-0325901 overcomes resistance to CK2 inhibitor CX-4945 and exhibits anti-tumor activity in head and neck cancer.

[2] Novel molecular targeted therapies for patients with neurofibromatosis type 1 with inoperable plexiform neurofibromas: a comprehensive review.

[3] The ground state of embryonic stem cell self-renewal.

[4] Pilot study of PD-0325901 in previously treated patients with advanced melanoma, breast cancer, and colon cancer.

[5] Phase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients with KRAS-mutation-positive colorectal, non-small-cell lung and pancreatic cancer.

[6] Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of Neurofibromatosis type 1.

[7] A phase II study of PD-0325901, an oral MEK inhibitor, in previously treated patients with advanced non-small cell lung cancer.

[8] MEK Inhibitor PD-0325901 Overcomes Resistance to PI3K/mTOR Inhibitor PF-5212384 and Potentiates Antitumor Effects in Human Head and Neck Squamous Cell Carcinoma.

[9] Phase I pharmacokinetic and pharmacodynamic study of the oral MAPK/ERK kinase inhibitor PD-0325901 in patients with advanced cancers.

[10] NF106: A Neurofibromatosis Clinical Trials Consortium Phase II Trial of the MEK Inhibitor Mirdametinib (PD-0325901) in Adolescents and Adults With NF1-Related Plexiform Neurofibromas.

TRANSCRIPTION FACTOR: STAG2

Gene Protein Amino acids More

STAG2
Cohesin subunit SA-2
1231
Uniport KEGGpathway