NETWORK ID: CN6161 | 

SREBF1 transcriptional regulatory sub-network

EXPERIMENTS
condition SB-590885
condition dose 3.33 uM
condition time 24 h
CELL LINE HEPG2
CONDITION DETALIS
ID BRD-K24496482
name SB-590885
type trt_cp; compound
molecular formula C27H27N5O2
molecular weight 453.5 g/mol
smiles
CN(C)CCOC1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC5=C(C=C4)C(=NO)CC5
clinical phase
None

Differential expressed genes in this transcriptional regulatory sub-network

If you want to view heatmap, you can click [expand]

You can download all DEGs data.

Symbolcontrolcontrolcontrolconditionconditioncondition
TSR111.026410.965810.921510.16549.6049.4467
REXO210.52859.94789.76438.28279.50118.3317
PFDN211.464911.589411.737710.375110.725210.948
TNFRSF12A10.304710.43069.64898.96349.06297.7466
RBM78.72018.26878.50897.66267.5897.6984
CDCA48.00778.67888.03436.92877.1056.3294
LYRM411.638910.427910.345910.19098.65978.3651
HEATR110.37699.651810.28558.92989.35228.2218
FNDC3B10.45399.94739.69138.95518.95638.9107
PUS18.96999.119.06328.03737.74868.3367
SLC35F28.42127.69017.50936.06966.33936.4644
RPL26L19.94579.44428.74838.47137.93497.6314
PAK1IP110.397510.600110.82498.96138.85859.4005
ZNHIT69.33159.23428.85488.45587.45797.447
FASTKD18.65498.63739.15068.06548.00357.5514
RRP1511.294310.073210.46559.21549.07999.3374
SLC17A97.73728.11397.77777.22336.61995.9795
ZNF5877.47437.89928.61667.01156.26856.9481
P3H19.16289.70169.35298.33858.87198.1117
MYL12B11.701911.725611.419410.18210.823910.4995
DENR10.663510.440810.12168.53859.1248.6879
GLS11.604211.92659.78619.5758.73368.5704
CRISPLD26.5035.3284.07323.26063.6623.6917
METTL511.19910.937611.320710.61199.70349.7669
CORO1C10.350310.5169.37958.21949.11058.3477
SEH1L11.923110.88811.09339.84159.08298.2423
SPATA5L18.67748.48989.4447.8057.61727.851
RDH148.69468.65798.09097.7836.67157.4822
KCNE45.40715.05985.90544.07454.24613.9178
EIF4G212.722512.133611.719610.769611.229910.7977
ZNF1469.19249.15038.90228.16928.18558.3821
HSP90B112.326312.375812.4210.960211.176511.228
DSP9.21659.29198.30827.14238.22027.0269
CSRP111.128811.516311.673110.577310.40799.5784
LDHA13.781412.757313.594311.78412.485411.3079
PHB13.441413.72612.660611.043812.648610.6289
PPP1CC12.369212.569312.226911.507511.415811.6051
RAN14.058813.709614.415813.276612.50712.76
ANXA513.843913.532912.553212.746711.248410.3685
ODC110.410811.229510.89958.32168.24947.8409
PPP1CA10.85479.95649.69988.73789.46018.1874
NOP5614.96214.580514.043913.333113.49212.7836
HSBP110.27889.723810.75339.5068.84478.6062
ALDOA9.24689.29898.42346.62858.24066.2786
ARF49.7479.40588.66888.43718.16457.8498
THBS18.64898.71449.26887.20346.88328.0492
PSMA713.583513.503813.400612.285613.011112.1618
SSB11.971412.234812.260611.142611.499310.9907
ITPR37.8797.28087.51386.86176.25785.718
ENO111.83511.038111.81849.939910.71299.1444
PSMD1310.983311.152910.92559.325810.56369.4417
HNRNPAB12.602712.962212.546311.759411.755211.3166
EBNA1BP210.800810.800310.55849.21669.03138.9918
DHX1511.640611.720210.2829.85529.52088.6574
NAP1L411.533311.406911.52169.965510.939310.3497
TALDO110.381910.24199.96418.84769.73378.3407
SRM12.008511.297411.732810.022410.65499.6746
NME114.756514.24481513.134213.360911.7898
FAT110.630310.299910.44199.39629.22038.6603
IFITM15.57915.25584.89523.74113.32433.533
IER312.168212.032311.68958.80888.81788.0716
PNP11.22911.48911.58139.950510.50549.6913
MTHFD211.459611.15911.192310.451710.22339.2213
TOMM3410.577310.31989.97678.69919.52738.7566
CCT212.587812.822112.684811.788311.938111.1769
IER210.06519.897510.38918.62789.43128.8396
TMED512.246711.853412.109311.355810.731711.3349
CBFB10.769310.192210.16289.50119.33517.9282
NUTF211.698310.094211.37689.96059.68299.1175
UBE2S11.115910.398911.26268.807310.39638.1959
INPP18.77518.7557.91357.46157.02376.2345
CDC2013.339213.298413.660412.260712.953412.2089
FHL29.1788.62888.75668.24817.43776.9061
CYBA9.04187.14437.11075.46336.90115.438
SNRPE13.355912.696512.808112.163411.642412.0256
ITGB1BP19.80799.61749.70463.91624.54999.0834
MTF29.76099.68119.44038.82248.77548.7168
MYCBP9.65159.27469.05858.05188.62547.4352
PSMG111.734911.077710.508310.30549.16368.3612
MMD9.12748.60648.62347.44357.30887.9508
MRPL1912.402212.275512.693711.710911.242611.2498
SLC7A67.09876.8656.35985.65525.68855.6495
PNO110.112810.240210.54498.10017.99298.9302
E2F39.08258.42098.47688.06846.67647.1582
MRPL1213.742613.987314.336212.704413.565512.6325
SLC5A611.15511.096610.95210.076710.51439.5099
MRPS1213.394413.872813.624812.241712.792412.772
FOSL18.38818.9748.38596.69747.56677.8138
DPH28.7978.38798.60477.3387.79967.1703
UCHL312.09711.134311.45229.939110.38029.5869
EEF1E113.167312.671613.452911.336310.368511.2775
HSPE114.893314.812514.626314.017113.372713.2519
SNRPG12.404411.291711.513910.958410.296910.3187
COMP3.33033.27452.6651.73381.56661.642
GAS29.26968.58748.82217.85857.96747.42
NOLC110.191810.01459.35828.95148.46218.4147
MATN38.40118.52878.68387.35677.5677.919
CNBP11.251511.67711.412810.930110.295110.3131
PRMT111.405811.244210.5539.142210.40798.4385
GLRX12.424512.131312.663910.97810.759710.3214
CPNE112.457612.419812.370110.992811.983511.1092
HSPH111.858812.118211.540610.760210.482110.4212
TFRC11.898212.708613.399211.391910.676510.4924
PCSK68.46278.49199.13747.84037.42027.6743
MAP2K38.69068.3668.22957.3527.357.0548
PDIA614.069714.23891512.510912.787513.5883
ACOT79.801810.375310.78488.68488.89628.8668
CLIC113.357613.102713.918811.959812.674312.1603
PRDX112.356211.901810.26649.794910.17988.268
YWHAB12.411112.483312.282710.525911.949911.14
ATIC11.780911.361112.480410.479110.512210.0908
MRPL310.845110.838311.35959.707810.17399.6057
ATP1B310.75879.547510.41258.82969.45428.2443
DUSP610.468910.401810.74297.36746.53997.4877
DDX1810.97910.642710.67689.95329.63499.2924
C1QBP14.540314.72241513.429913.35913.0977
EIF3J9.90049.74019.76998.53468.09598.6442
TSPAN410.863911.015210.65169.32969.9817.9653
ADCY35.19154.84634.48023.05054.04473.7908
UAP19.24988.56467.58836.8237.20545.8613
BANF110.819311.066311.388810.110410.31719.4636
TPM110.714310.7769.65279.10129.39928.0412
POLR2L13.723613.498612.408310.969812.471311.0878
PSMD1411.623912.067111.975810.7389.898810.5064
IMP411.906912.731513.469611.048211.291611.638
GRPEL110.601710.80279.80179.29419.62698.9795
PPP1R14B9.52759.30849.54358.7538.3468.3897
RPIA11.901611.566711.802410.733110.960310.1369
TFPI12.956311.650310.212910.61918.84018.2221
PFAS11.296210.561910.607510.00019.11779.195
RPP409.96029.30798.79828.38298.06697.5498
COL2A16.50247.22416.5585.33295.1275.2755
F2RL18.0078.67668.4956.27476.50636.9812
HOMER17.66666.17666.09275.02225.4754.7357
DHRS212.005812.378311.424510.550810.71539.0119
BCAT17.45686.40096.11275.62364.53413.9098
WDR4310.649610.19799.88339.25968.71158.2084
TM4SF19.537310.86879.55928.04987.02444.6455
GTF3A11.194110.61611.182110.27489.93489.3252
ACP111.127611.201311.642310.230110.187510.5511
FASTKD210.780710.866810.948710.096810.00299.9696
POMP12.392211.785111.625810.741510.580610.5204
PRMT511.75211.73411.937610.49410.516810.1712
PPA111.400911.704811.235210.378810.286310.2614
CMPK110.25659.88299.10639.02548.15338.0246
AKIRIN110.18988.88138.83698.02898.09497.983
HSD17B1110.796310.407910.52819.7249.08989.4733
PHLDA18.76417.99287.02963.54725.33175.6223
NDC19.52489.76829.52688.78588.33018.1128
SRPRB10.17359.50728.36868.22047.90426.9184

SREBF1 transcriptional regulatory sub-network

The possible genes regulated by the transcription factor were obtained by calculation, and the results were displayed in the form of network

More information of [SB-590885] and [SREBF1]. Click to[expand]

Curated target protein/gene of this condition/drug

Protein target or gene target of this condition curated by previous studies and their associated KEGG pathways are shown below

Target Gene Protein Amino acids More

BRAF
Serine/threonine-protein kinase B-raf
766
Uniport KEGGpathway

ARTICLE: SB-590885

[1] Concentration-Dependent Dual Effects of Ciprofloxacin on SB-590885-Resistant BRAFV600E A375 Melanoma Cells.

[2] Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885.

[3] The identification of potent and selective imidazole-based inhibitors of B-Raf kinase.

[4] The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase.

[5] Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K.

[6] Pan-Cancer Analysis of the TRP Family, Especially TRPV4 and TRPC4, and Its Expression Correlated with Prognosis, Tumor Microenvironment, and Treatment Sensitivity.

[7] Germline mutations of MEK in cardio-facio-cutaneous syndrome are sensitive to MEK and RAF inhibition: implications for therapeutic options.

[8] An Integrative Pharmacogenomic Approach Identifies Two-drug Combination Therapies for Personalized Cancer Medicine.

TRANSCRIPTION FACTOR: SREBF1

Gene Protein Amino acids More

SREBF1
Sterol regulatory element-binding protein 1
1147
Uniport KEGGpathway

ARTICLE: SREBF1

[1] PRP19 Enhances Esophageal Squamous Cell Carcinoma Progression by Reprogramming SREBF1-Dependent Fatty Acid Metabolism.

[2] Apolipoprotein A4 Restricts Diet-Induced Hepatic Steatosis via SREBF1-Mediated Lipogenesis and Enhances IRS-PI3K-Akt Signaling.

[3] Srebf1 Controls Midbrain Dopaminergic Neurogenesis.

[4] Extracellular Vesicle-Packaged circATP2B4 Mediates M2 Macrophage Polarization via miR-532-3p/SREBF1 Axis to Promote Epithelial Ovarian Cancer Metastasis.

[5] Aberrant elevation of FTO levels promotes liver steatosis by decreasing the m6A methylation and increasing the stability of SREBF1 and ChREBP mRNAs.

[6] Role of AMP-activated protein kinase in mechanism of metformin action.

[7] SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.

[8] SREBF1 Activity Is Regulated by an AR/mTOR Nuclear Axis in Prostate Cancer.